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2017 ; 34
(5
): 405-417
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gab.com Text
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The role of regulatory T cells and genes involved in their differentiation in
pathogenesis of selected inflammatory and neoplastic skin diseases Part II: The
Treg role in skin diseases pathogenesis
#MMPMID29507554
Nedoszytko B
; Lange M
; Soko?owska-Wojdy?o M
; Renke J
; Trzonkowski P
; Sobjanek M
; Szczerkowska-Dobosz A
; Niedoszytko M
; Górska A
; Romantowski J
; Czarny J
; Skokowski J
; Kalinowski L
; Nowicki R
Postepy Dermatol Alergol
2017[Oct]; 34
(5
): 405-417
PMID29507554
show ga
Regulatory FOXP3+ T cells (Tregs) constitute 5% to 10% of T cells in the normal
human skin. They play an important role in the induction and maintenance of
immunological tolerance. The suppressive effects of these cells are exerted by
various mechanisms including the direct cytotoxic effect, anti-inflammatory
cytokines, metabolic disruption, and modulation of the dendritic cells function.
The deficiency of Treg cells number or function are one of the basic elements of
the pathogenesis of many skin diseases, such as psoriasis, atopic dermatitis,
bacterial and viral infections. They also play a role in the pathogenesis of T
cell lymphomas of the skin (cutaneous T cell lymphomas - CTCL), skin tumors and
mastocytosis. Here, in the second part of the cycle, we describe dysfunctions of
Tregs in selected skin diseases.