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2018 ; 15
(4
): 4592-4598
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Nicotinamide N-methyltransferase promotes epithelial-mesenchymal transition in
gastric cancer cells by activating transforming growth factor-?1 expression
#MMPMID29541230
Liang L
; Zeng M
; Pan H
; Liu H
; He Y
Oncol Lett
2018[Apr]; 15
(4
): 4592-4598
PMID29541230
show ga
Previous studies have demonstrated that nicotinamide N-methyltransferase (NNMT)
is aberrantly expressed in a number of tumors. In the present study, it was
demonstrated that the gene and protein levels of NNMT were significantly
increased in gastric cancer cells. Furthermore, upregulation of NNMT
significantly increased the expression of mesenchymal markers, including ?-smooth
muscle actin (SMA), vimentin and fibronectin, but decreased the levels of
epithelial cadherin. Since transforming growth factor (TGF)-?1 may serve a key
function in epithelial-mesenchymal transition (EMT), the effects of NNMT on the
expression of TGF-?1 were investigated in BGC-823 cells. The results demonstrated
that overexpression of NNMT significantly induced the expression of TGF-?1.
However, knockdown of NNMT inhibited the expression of TGF-?1, mothers against
decapentaplegic homolog (Smad)2 and ?-SMA. Additionally, pre-incubation with
TGF-?1 partially eliminated NNMT-mediated changes in EMT. Collectively, the
results demonstrated that upregulation of NNMT in gastric cancer cells may
increase the expression of TGF-?1, therefore activating TGF-?1/Smad signaling,
which in turn promotes EMT.
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