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10.1111/joa.12691 http://scihub22266oqcxt.onion/10.1111/joa.12691 C5835792!5835792!29023694     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Anat 2018 ; 232 (4): 524-33 Nephropedia Template TP {{tp|p=29023694|t=2018. Adaptive self?organization in the embryo: its importance to adult anatomy and to tissue engineering |pdf=|usr=}}{{29023694}} gab.com Text Adaptive self organization in the embryo: its importance to adult anatomy and to tissue engineering JO: J Anat http://www.kidney.de/pget.php?&tw=1&pmid=29023694 #FOAvip The anatomy of healthy humans shows much minor variation, and twin?studies reveal at least some of this variation cannot be explained genetically. A plausible explanation is that fine?scale anatomy is not specified directly in a genetic programme, but emerges from self?organizing behaviours of cells that, for example, place a new capillary where it happens to be needed to prevent local hypoxia. Self?organizing behaviour can be identified by manipulating growing tissues (e.g. putting them under a spatial constraint) and observing an adaptive change that conserves the character of the normal tissue while altering its precise anatomy. Self?organization can be practically useful in tissue engineering but it is limited; generally, it is good for producing realistic small?scale anatomy but large?scale features will be missing. This is because self?organizing organoids miss critical symmetry?breaking influences present in the embryo: simulating these artificially, for example, with local signal sources, makes anatomy realistic even at large scales. A growing understanding of the mechanisms of self?organization is now allowing synthetic biologists to take their first tentative steps towards constructing artificial multicellular systems that spontaneously organize themselves into patterns, which may soon be extended into three?dimensional shapes. Twit Text FOAVip Adaptive self organization in the embryo: its importance to adult anatomy and to tissue engineering ????J Anat http://www.kidney.de/pget.php?&tw=1&pmid=29023694 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29023694 #FOAvip English Wikipedia <ref>{{Cite pmid|29023694}}</ref> Adaptive self?organization in the embryo: its importance to adult anatomy and to tissue engineering #MMPMID29023694 Davies JA J Anat 2018[Apr]; 232 (4): 524-33 PMID29023694show ga The anatomy of healthy humans shows much minor variation, and twin?studies reveal at least some of this variation cannot be explained genetically. A plausible explanation is that fine?scale anatomy is not specified directly in a genetic programme, but emerges from self?organizing behaviours of cells that, for example, place a new capillary where it happens to be needed to prevent local hypoxia. Self?organizing behaviour can be identified by manipulating growing tissues (e.g. putting them under a spatial constraint) and observing an adaptive change that conserves the character of the normal tissue while altering its precise anatomy. Self?organization can be practically useful in tissue engineering but it is limited; generally, it is good for producing realistic small?scale anatomy but large?scale features will be missing. This is because self?organizing organoids miss critical symmetry?breaking influences present in the embryo: simulating these artificially, for example, with local signal sources, makes anatomy realistic even at large scales. A growing understanding of the mechanisms of self?organization is now allowing synthetic biologists to take their first tentative steps towards constructing artificial multicellular systems that spontaneously organize themselves into patterns, which may soon be extended into three?dimensional shapes. äAdaptive self?organization in the embryo: its importance to adult anat(epmc).pdf DeepDyve Pubget Overpricing