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10.1042/BSR20171294 http://scihub22266oqcxt.onion/10.1042/BSR20171294 C5835716!5835716!29330224     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biosci+Rep 2018 ; 38 (2): ä Nephropedia Template TP {{tp|p=29330224|t=2018. Vitamin D ameliorates impaired wound healing in streptozotocin-induced diabetic mice by suppressing NF-?B-mediated inflammatory genes |pdf=|usr=}}{{29330224}} gab.com Text Vitamin D ameliorates impaired wound healing in streptozotocin-induced diabetic mice by suppressing NF- B-mediated inflammatory genes JO: Biosci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29330224 #FOAvip Diabetic wounds are characterized by delayed wound healing due to persistent inflammation and excessive production of reactive oxygen species. Vitamin D, which is well acknowledged to enhance intestinal calcium absorption and increase in plasma calcium level, has recently been shown to display beneficial effects in various vascular diseases by promoting angiogenesis and inhibiting inflammatory responses. However, the role of Vitamin D in diabetic wound healing is still unclear. In the present study, we investigated the role of Vitamin D in cutaneous wound healing in streptozotocin (STZ)-induced diabetic mice. Four weeks after injection of STZ, a full thickness excisional wound was created with a 6-mm diameter sterile biopsy punch on the dorsum of the mice. Vitamin D was given consecutively for 14 days by intraperitoneal injection. Vitamin D supplementation significantly accelerated wound healing in diabetic mice and improved the healing quality as assessed by measuring the wound closure rate and histomorphometric analyses. By monitoring the level of pro-inflammatory cytokines tumor necrosis factor-? (TNF-?), interleukin (IL) 6 (IL-6), IL-1?) in the wounds, reduced inflammatory response was found in VD treatment group. Furthermore, nuclear factor ?B (NF-?B) pathway was found to be involved in the process of diabetic wound healing by assessing the relative proteins in diabetic wounds. Vitamin D supplementation obviously suppressed NF-?B pathway activation. These results demonstrated that Vitamin D improves impaired wound healing in STZ-induced diabetic mice through suppressing NF-?B-mediated inflammatory gene expression. Twit Text FOAVip Vitamin D ameliorates impaired wound healing in streptozotocin-induced diabetic mice by suppressing NF- B-mediated inflammatory genes ????Biosci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29330224 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29330224 #FOAvip English Wikipedia <ref>{{Cite pmid|29330224}}</ref> Vitamin D ameliorates impaired wound healing in streptozotocin-induced diabetic mice by suppressing NF-?B-mediated inflammatory genes #MMPMID29330224 Yuan Y; Das S; Li M Biosci Rep 2018[Apr]; 38 (2): ä PMID29330224show ga Diabetic wounds are characterized by delayed wound healing due to persistent inflammation and excessive production of reactive oxygen species. Vitamin D, which is well acknowledged to enhance intestinal calcium absorption and increase in plasma calcium level, has recently been shown to display beneficial effects in various vascular diseases by promoting angiogenesis and inhibiting inflammatory responses. However, the role of Vitamin D in diabetic wound healing is still unclear. In the present study, we investigated the role of Vitamin D in cutaneous wound healing in streptozotocin (STZ)-induced diabetic mice. Four weeks after injection of STZ, a full thickness excisional wound was created with a 6-mm diameter sterile biopsy punch on the dorsum of the mice. Vitamin D was given consecutively for 14 days by intraperitoneal injection. Vitamin D supplementation significantly accelerated wound healing in diabetic mice and improved the healing quality as assessed by measuring the wound closure rate and histomorphometric analyses. By monitoring the level of pro-inflammatory cytokines tumor necrosis factor-? (TNF-?), interleukin (IL) 6 (IL-6), IL-1?) in the wounds, reduced inflammatory response was found in VD treatment group. Furthermore, nuclear factor ?B (NF-?B) pathway was found to be involved in the process of diabetic wound healing by assessing the relative proteins in diabetic wounds. Vitamin D supplementation obviously suppressed NF-?B pathway activation. These results demonstrated that Vitamin D improves impaired wound healing in STZ-induced diabetic mice through suppressing NF-?B-mediated inflammatory gene expression. äVitamin D ameliorates impaired wound healing in streptozotocin-induced(epmc).pdf DeepDyve Pubget Overpricing