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10.1155/2018/6215350 http://scihub22266oqcxt.onion/10.1155/2018/6215350 C5835271!5835271!29670465     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mediators+Inflamm 2018 ; 2018 (ä): ä Nephropedia Template TP {{tp|p=29670465|t=2018. Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction |pdf=|usr=}}{{29670465}} gab.com Text Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=29670465 #FOAvip Postoperative cognitive dysfunction (POCD), a long-lasting cognitive decline after surgery, is currently a major clinical problem with no clear pathophysiological mechanism or effective therapy. Accumulating evidence suggests that neuroinflammation plays a critical role in POCD. After surgery, alarmins are leaked from the injury sites and proinflammatory cytokines are increased in the peripheral circulation. Neurons in the hippocampus, which is responsible for learning and memory, can be damaged by cytokines transmitted to the brain parenchyma. Microglia, bone marrow-derived macrophages, mast cells, and T cells in the central nervous system (CNS) can be activated to secrete more cytokines, further aggravating neuroinflammation after surgery. Conversely, blocking the inflammation network between these immune cells and related cytokines alleviates POCD in experimental animals. Thus, a deeper understanding of the roles of immune cells and the crosstalk between them in POCD may uncover promising therapeutic targets for POCD treatment and prevention. Here, we reviewed several major immune cells and discussed their functional roles in POCD. Twit Text FOAVip Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=29670465 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29670465 #FOAvip English Wikipedia <ref>{{Cite pmid|29670465}}</ref> Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction #MMPMID29670465 Liu Y; Yin Y Mediators Inflamm 2018[]; 2018 (ä): ä PMID29670465show ga Postoperative cognitive dysfunction (POCD), a long-lasting cognitive decline after surgery, is currently a major clinical problem with no clear pathophysiological mechanism or effective therapy. Accumulating evidence suggests that neuroinflammation plays a critical role in POCD. After surgery, alarmins are leaked from the injury sites and proinflammatory cytokines are increased in the peripheral circulation. Neurons in the hippocampus, which is responsible for learning and memory, can be damaged by cytokines transmitted to the brain parenchyma. Microglia, bone marrow-derived macrophages, mast cells, and T cells in the central nervous system (CNS) can be activated to secrete more cytokines, further aggravating neuroinflammation after surgery. Conversely, blocking the inflammation network between these immune cells and related cytokines alleviates POCD in experimental animals. Thus, a deeper understanding of the roles of immune cells and the crosstalk between them in POCD may uncover promising therapeutic targets for POCD treatment and prevention. Here, we reviewed several major immune cells and discussed their functional roles in POCD. äEmerging Roles of Immune Cells in Postoperative Cognitive Dysfunction (epmc).pdf DeepDyve Pubget Overpricing