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Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Mediators+Inflamm 2018 ; 2018 (ä): ä Nephropedia Template TP
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V?4+ T Cells: A Novel IL-17-Producing ?? T Subsets during the Early Phase of Chlamydial Airway Infection in Mice #MMPMID29670466
Sun Ld; Qiao S; Wang Y; Pang Gj; Zha Xy; Liu TL; Zhao HL; Liang JY; Zheng Nb; Tan L; Zhang H; Bai H
Mediators Inflamm 2018[]; 2018 (ä): ä PMID29670466show ga
Our previous studies showed that ?? T cells provided immune protection against Chlamydial muridarum (Cm), an obligate intracellular strain of chlamydia trachomatis, lung infection by producing abundant IL-17. In this study, we investigated the proliferation and activation of lung ?? T cell subsets, specifically the IL-17 and IFN? production by them following Cm lung infection. Our results found that five ?? T cell subsets, V?1+ T, V?2+ T, V?4+ T, V?5+ T, and V?6+ T, expressed in lungs of naïve mice, while Cm lung infection mainly induced the proliferation and activation of V?4+ T cells at day 3 p.i., following V?1+ T cells at day 7 p.i. Cytokine detection showed that Cm lung infection induced IFN? secretion firstly by V?4+ T cells at very early stage (day 3) and changed to V?1+ T cells at midstage (day 7). Furthermore, V?4+ T cell is the main ?? T cell subset that secretes IL-17 at the very early stage of Cm lung infection and V?1+ T cell did not secrete IL-17 during the infection. These findings provide in vivo evidence that V?4+T cells are the major IL-17 and IFN?-producing ?? T cell subsets at the early period of Cm lung infection.