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10.3389/fimmu.2018.00341 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00341 C5834761!5834761!29535722     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29535722|t=2018. Optimizing Tumor Microenvironment for Cancer Immunotherapy: ?-Glucan-Based Nanoparticles |pdf=|usr=}}{{29535722}} gab.com Text Optimizing Tumor Microenvironment for Cancer Immunotherapy: -Glucan-Based Nanoparticles JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29535722 #FOAvip Immunotherapy is revolutionizing cancer treatment. Recent clinical success with immune checkpoint inhibitors, chimeric antigen receptor T-cell therapy, and adoptive immune cellular therapies has generated excitement and new hopes for patients and investigators. However, clinically efficacious responses to cancer immunotherapy occur only in a minority of patients. One reason is the tumor microenvironment (TME), which potently inhibits the generation and delivery of optimal antitumor immune responses. As our understanding of TME continues to grow, strategies are being developed to change the TME toward one that augments the emergence of strong antitumor immunity. These strategies include eliminating tumor bulk to provoke the release of tumor antigens, using adjuvants to enhance antigen-presenting cell function, and employ agents that enhance immune cell effector activity. This article reviews the development of ?-glucan and ?-glucan-based nanoparticles as immune modulators of TME, as well as their potential benefit and future therapeutic applications. Cell-wall ?-glucans from natural sources including plant, fungi, and bacteria are molecules that adopt pathogen-associated molecular pattern (PAMP) known to target specific receptors on immune cell subsets. Emerging data suggest that the TME can be actively manipulated by ?-glucans and their related nanoparticles. In this review, we discuss the mechanisms of conditioning TME using ?-glucan and ?-glucan-based nanoparticles, and how this strategy enables future design of optimal combination cancer immunotherapies. Twit Text FOAVip Optimizing Tumor Microenvironment for Cancer Immunotherapy: -Glucan-Based Nanoparticles ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29535722 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29535722 #FOAvip English Wikipedia <ref>{{Cite pmid|29535722}}</ref> Optimizing Tumor Microenvironment for Cancer Immunotherapy: ?-Glucan-Based Nanoparticles #MMPMID29535722 Zhang M; Kim JA; Huang AYC Front Immunol 2018[]; 9 (ä): ä PMID29535722show ga Immunotherapy is revolutionizing cancer treatment. Recent clinical success with immune checkpoint inhibitors, chimeric antigen receptor T-cell therapy, and adoptive immune cellular therapies has generated excitement and new hopes for patients and investigators. However, clinically efficacious responses to cancer immunotherapy occur only in a minority of patients. One reason is the tumor microenvironment (TME), which potently inhibits the generation and delivery of optimal antitumor immune responses. As our understanding of TME continues to grow, strategies are being developed to change the TME toward one that augments the emergence of strong antitumor immunity. These strategies include eliminating tumor bulk to provoke the release of tumor antigens, using adjuvants to enhance antigen-presenting cell function, and employ agents that enhance immune cell effector activity. This article reviews the development of ?-glucan and ?-glucan-based nanoparticles as immune modulators of TME, as well as their potential benefit and future therapeutic applications. Cell-wall ?-glucans from natural sources including plant, fungi, and bacteria are molecules that adopt pathogen-associated molecular pattern (PAMP) known to target specific receptors on immune cell subsets. Emerging data suggest that the TME can be actively manipulated by ?-glucans and their related nanoparticles. In this review, we discuss the mechanisms of conditioning TME using ?-glucan and ?-glucan-based nanoparticles, and how this strategy enables future design of optimal combination cancer immunotherapies. äOptimizing Tumor Microenvironment for Cancer Immunotherapy: ?-Glucan-B(epmc).pdf DeepDyve Pubget Overpricing