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10.1038/s41467-018-03342-5 http://scihub22266oqcxt.onion/10.1038/s41467-018-03342-5 C5834599!5834599 !29500350     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29500350 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2018 ; 9 (1 ): 932 Nephropedia Template TP {{tp|p=29500350 |t=2018. Strong selection during the last millennium for African ancestry in the admixed population of Madagascar |pdf=|usr=}}{{29500350 }} gab.com Text Strong selection during the last millennium for African ancestry in the admixed population of Madagascar JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29500350 #FOAvip While admixed populations offer a unique opportunity to detect selection, the admixture in most of the studied populations occurred too recently to produce conclusive signals. By contrast, Malagasy populations originate from admixture between Asian and African populations that occurred ~27 generations ago, providing power to detect selection. We analyze local ancestry across the genomes of 700 Malagasy and identify a strong signal of recent positive selection, with an estimated selection coefficient >0.2. The selection is for African ancestry and affects 25% of chromosome 1, including the Duffy blood group gene. The null allele at this gene provides resistance to Plasmodium vivax malaria, and previous studies have suggested positive selection for this allele in the Malagasy population. This selection event also influences numerous other genes implicated in immunity, cardiovascular diseases, and asthma and decreases the Asian ancestry genome-wide by 10%, illustrating the role played by selection in recent human history. Twit Text FOAVip Strong selection during the last millennium for African ancestry in the admixed population of Madagascar ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29500350 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29500350 #FOAvip English Wikipedia <ref>{{Cite pmid|29500350 }}</ref> Strong selection during the last millennium for African ancestry in the admixed population of Madagascar #MMPMID29500350 Pierron D ; Heiske M ; Razafindrazaka H ; Pereda-Loth V ; Sanchez J ; Alva O ; Arachiche A ; Boland A ; Olaso R ; Deleuze JF ; Ricaut FX ; Rakotoarisoa JA ; Radimilahy C ; Stoneking M ; Letellier T Nat Commun 2018[Mar]; 9 (1 ): 932 PMID29500350 show ga While admixed populations offer a unique opportunity to detect selection, the admixture in most of the studied populations occurred too recently to produce conclusive signals. By contrast, Malagasy populations originate from admixture between Asian and African populations that occurred ~27 generations ago, providing power to detect selection. We analyze local ancestry across the genomes of 700 Malagasy and identify a strong signal of recent positive selection, with an estimated selection coefficient >0.2. The selection is for African ancestry and affects 25% of chromosome 1, including the Duffy blood group gene. The null allele at this gene provides resistance to Plasmodium vivax malaria, and previous studies have suggested positive selection for this allele in the Malagasy population. This selection event also influences numerous other genes implicated in immunity, cardiovascular diseases, and asthma and decreases the Asian ancestry genome-wide by 10%, illustrating the role played by selection in recent human history. |*Genome, Human [MESH] |*Genome-Wide Association Study [MESH] |*Selection, Genetic [MESH] |Black People/genetics [MESH] |Duffy Blood-Group System/genetics [MESH] |Humans [MESH] |Madagascar [MESH]Strong selection during the last millennium for African ancestry in th(epmc).pdf DeepDyve Pubget Overpricing