Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29541423
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncotarget
2018 ; 9
(13
): 11414-11426
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Role of novel histone modifications in cancer
#MMPMID29541423
Shanmugam MK
; Arfuso F
; Arumugam S
; Chinnathambi A
; Jinsong B
; Warrier S
; Wang LZ
; Kumar AP
; Ahn KS
; Sethi G
; Lakshmanan M
Oncotarget
2018[Feb]; 9
(13
): 11414-11426
PMID29541423
show ga
Oncogenesis is a multistep process mediated by a variety of factors including
epigenetic modifications. Global epigenetic post-translational modifications have
been detected in almost all cancers types. Epigenetic changes appear briefly and
do not involve permanent changes to the primary DNA sequence. These epigenetic
modifications occur in key oncogenes, tumor suppressor genes, and transcription
factors, leading to cancer initiation and progression. The most commonly observed
epigenetic changes include DNA methylation, histone lysine methylation and
demethylation, histone lysine acetylation and deacetylation. However, there are
several other novel post-translational modifications that have been observed in
recent times such as neddylation, sumoylation, glycosylation, phosphorylation,
poly-ADP ribosylation, ubiquitination as well as transcriptional regulation and
these have been briefly discussed in this article. We have also highlighted the
diverse epigenetic changes that occur during the process of tumorigenesis and
described the role of histone modifications that can occur on tumor suppressor
genes as well as oncogenes, which regulate tumorigenesis and can thus form the
basis of novel strategies for cancer therapy.
free
free
free
