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10.1038/nmeth.4579

http://scihub22266oqcxt.onion/10.1038/nmeth.4579
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C5833950!5833950!29355847
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suck abstract from ncbi


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pmid29355847      Nat+Methods 2018 ; 15 (3): 183-6
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  • EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens #MMPMID29355847
  • Squadrito ML; Cianciaruso C; Hansen SK; De Palma M
  • Nat Methods 2018[Mar]; 15 (3): 183-6 PMID29355847show ga
  • We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated tumor antigens to CD8+ T cells primarily through MHCI recycling and cross-dressing. EVIR-engineered DCs may increase the applications of DC-based cancer vaccines.
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