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10.1038/nmat3627 http://scihub22266oqcxt.onion/10.1038/nmat3627 C5833942!5833942 !23603848     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23603848 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Mater 2013 ; 12 (6 ): 576-83 Nephropedia Template TP {{tp|p=23603848 |t=2013. Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification |pdf=|usr=}}{{23603848 }} gab.com Text Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification JO: Nat Mater http://www.kidney.de/pget.php?&tw=1&pmid=23603848 #FOAvip The accumulation of calcified material in cardiovascular tissue is thought to involve cytochemical, extracellular matrix and systemic signals; however, its precise composition and nanoscale architecture remain largely unexplored. Using nano-analytical electron microscopy techniques, we examined valves, aortae and coronary arteries from patients with and without calcific cardiovascular disease and detected spherical calcium phosphate particles, regardless of the presence of calcific lesions. We also examined lesions after sectioning with a focused ion beam and found that the spherical particles are composed of highly crystalline hydroxyapatite that crystallographically and structurally differs from bone mineral. Taken together, these data suggest that mineralized spherical particles may play a fundamental role in calcific lesion formation. Their ubiquitous presence in varied cardiovascular tissues and from patients with a spectrum of diseases further suggests that lesion formation may follow a common process. Indeed, applying materials science techniques to ectopic and orthotopic calcification has great potential to lend critical insights into pathophysiological processes underlying calcific cardiovascular disease. Twit Text FOAVip Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification ????Nat Mater http://www.kidney.de/pget.php?&tw=1&pmid=23603848 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23603848 #FOAvip English Wikipedia <ref>{{Cite pmid|23603848 }}</ref> Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification #MMPMID23603848 Bertazzo S ; Gentleman E ; Cloyd KL ; Chester AH ; Yacoub MH ; Stevens MM Nat Mater 2013[Jun]; 12 (6 ): 576-83 PMID23603848 show ga The accumulation of calcified material in cardiovascular tissue is thought to involve cytochemical, extracellular matrix and systemic signals; however, its precise composition and nanoscale architecture remain largely unexplored. Using nano-analytical electron microscopy techniques, we examined valves, aortae and coronary arteries from patients with and without calcific cardiovascular disease and detected spherical calcium phosphate particles, regardless of the presence of calcific lesions. We also examined lesions after sectioning with a focused ion beam and found that the spherical particles are composed of highly crystalline hydroxyapatite that crystallographically and structurally differs from bone mineral. Taken together, these data suggest that mineralized spherical particles may play a fundamental role in calcific lesion formation. Their ubiquitous presence in varied cardiovascular tissues and from patients with a spectrum of diseases further suggests that lesion formation may follow a common process. Indeed, applying materials science techniques to ectopic and orthotopic calcification has great potential to lend critical insights into pathophysiological processes underlying calcific cardiovascular disease. |Aorta/pathology/ultrastructure [MESH] |Calcification, Physiologic [MESH] |Calcinosis/*pathology [MESH] |Calcium Phosphates/analysis [MESH] |Cardiomyopathies/*pathology [MESH] |Coronary Vessels/pathology/ultrastructure [MESH] |Durapatite/analysis [MESH] |Heart Valve Diseases/pathology [MESH] |Heart Valves/pathology/ultrastructure [MESH] |Humans [MESH] |Microscopy, Electron, Scanning [MESH] |Microscopy, Electron/*methods [MESH] |Nanotechnology/methods [MESH]Nano-analytical electron microscopy reveals fundamental insights into (epmc).pdf DeepDyve Pubget Overpricing