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10.1038/s41389-017-0025-3 http://scihub22266oqcxt.onion/10.1038/s41389-017-0025-3 C5833873!5833873!29362397     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogenesis 2018 ; 7 (1): ä Nephropedia Template TP {{tp|p=29362397|t=2018. Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases |pdf=|usr=}}{{29362397}} gab.com Text Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases JO: Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=29362397 #FOAvip Glutathione transferase classical GSH conjugation activity plays a critical role in cellular detoxification against xenobiotics and noxious compounds as well as against oxidative stress. However, this feature is also exploited by cancer cells to acquire drug resistance and improve their survival. As a result, various members of the family were found overexpressed in a number of different cancers. Moreover several GST polymorphisms, ranging from null phenotypes to point mutations, were detected in members of the family and found to correlate with the onset of neuro-degenerative diseases. In the last decades, a great deal of research aimed at clarifying the role played by GSTs in drug resistance, at developing inhibitors to counteract this activity but also at exploiting GSTs for prodrugs specific activation in cancer cells. Here we summarize some of the most important achievements reached in this lively area of research. Twit Text FOAVip Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases ????Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=29362397 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29362397 #FOAvip English Wikipedia <ref>{{Cite pmid|29362397}}</ref> Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases #MMPMID29362397 Allocati N; Masulli M; Di Ilio C; Federici L Oncogenesis 2018[Jan]; 7 (1): ä PMID29362397show ga Glutathione transferase classical GSH conjugation activity plays a critical role in cellular detoxification against xenobiotics and noxious compounds as well as against oxidative stress. However, this feature is also exploited by cancer cells to acquire drug resistance and improve their survival. As a result, various members of the family were found overexpressed in a number of different cancers. Moreover several GST polymorphisms, ranging from null phenotypes to point mutations, were detected in members of the family and found to correlate with the onset of neuro-degenerative diseases. In the last decades, a great deal of research aimed at clarifying the role played by GSTs in drug resistance, at developing inhibitors to counteract this activity but also at exploiting GSTs for prodrugs specific activation in cancer cells. Here we summarize some of the most important achievements reached in this lively area of research. äGlutathione transferases: substrates, inihibitors and pro-drugs in can(epmc).pdf DeepDyve Pubget Overpricing