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10.1038/s41389-017-0011-9 http://scihub22266oqcxt.onion/10.1038/s41389-017-0011-9 C5833859!5833859!29362402     free     free     free       Oncogenesis 2018 ; 7 (1): ä Nephropedia Template TP {{tp|p=29362402|t=2018. The hypoxic tumour microenvironment |pdf=|usr=}}{{29362402}} gab.com Text The hypoxic tumour microenvironment JO: Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=29362402 #FOAvip Cancer progression often benefits from the selective conditions present in the tumour microenvironment, such as the presence of cancer-associated fibroblasts (CAFs), deregulated ECM deposition, expanded vascularisation and repression of the immune response. Generation of a hypoxic environment and activation of its main effector, hypoxia-inducible factor-1 (HIF-1), are common features of advanced cancers. In addition to the impact on tumour cell biology, the influence that hypoxia exerts on the surrounding cells represents a critical step in the tumorigenic process. Hypoxia indeed enables a number of events in the tumour microenvironment that lead to the expansion of aggressive clones from heterogeneous tumour cells and promote a lethal phenotype. In this article, we review the most relevant findings describing the influence of hypoxia and the contribution of HIF activation on the major components of the tumour microenvironment, and we summarise their role in cancer development and progression. Twit Text FOAVip The hypoxic tumour microenvironment ????Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=29362402 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29362402 #FOAvip English Wikipedia <ref>{{Cite pmid|29362402}}</ref> The hypoxic tumour microenvironment #MMPMID29362402 Petrova V; Annicchiarico-Petruzzelli M; Melino G; Amelio I Oncogenesis 2018[Jan]; 7 (1): ä PMID29362402show ga Cancer progression often benefits from the selective conditions present in the tumour microenvironment, such as the presence of cancer-associated fibroblasts (CAFs), deregulated ECM deposition, expanded vascularisation and repression of the immune response. Generation of a hypoxic environment and activation of its main effector, hypoxia-inducible factor-1 (HIF-1), are common features of advanced cancers. In addition to the impact on tumour cell biology, the influence that hypoxia exerts on the surrounding cells represents a critical step in the tumorigenic process. Hypoxia indeed enables a number of events in the tumour microenvironment that lead to the expansion of aggressive clones from heterogeneous tumour cells and promote a lethal phenotype. In this article, we review the most relevant findings describing the influence of hypoxia and the contribution of HIF activation on the major components of the tumour microenvironment, and we summarise their role in cancer development and progression. äThe hypoxic tumour microenvironment (epmc).pdf DeepDyve Pubget Overpricing