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10.1038/s41419-018-0333-3 http://scihub22266oqcxt.onion/10.1038/s41419-018-0333-3 C5833788!5833788!29449642     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2018 ; 9 (3): ä Nephropedia Template TP {{tp|p=29449642|t=2018. NIT1 suppresses tumour proliferation by activating the TGF?1?Smad2/3 signalling pathway in colorectal cancer |pdf=|usr=}}{{29449642}} gab.com Text NIT1 suppresses tumour proliferation by activating the TGF 1 Smad2/3 signalling pathway in colorectal cancer JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29449642 #FOAvip NIT1 protein has been reported to be a potential tumour suppressor in tumour progression. However, little is known about the specific role of NIT1 in tumour development and progression. In this study, we confirmed the specific effects of NIT1 in the regulation of colorectal carcinoma cell proliferation. Here, we showed that NIT1 was significantly downregulated in colorectal cancer tissues compared with that in adjacent normal tissues. The decreased expression of NIT1 was significantly correlated with poor differentiation and more serosal invasion. Functional experiments showed that NIT1 inhibited CRC cell growth both in vitro and in vivo. NIT1 induced cell cycle arrest and apoptosis. Furthermore, NIT1 recruited Smad2/3 to the TGF? receptor and activated the TGF??Smad2/3 pathway by interacting with SARA and SMAD2/3 in CRC. Further study has shown that SMAD3 directly binds to the promoter regions of NIT1 and enhances the transcription of NIT1. Together, our findings indicate that NIT1 suppresses CRC proliferation through a positive feedback loop between NIT1 and activation of the TGF??Smad signalling pathway. This study might provide a new promising strategy for CRC. Twit Text FOAVip NIT1 suppresses tumour proliferation by activating the TGF 1 Smad2/3 signalling pathway in colorectal cancer ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29449642 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29449642 #FOAvip English Wikipedia <ref>{{Cite pmid|29449642}}</ref> NIT1 suppresses tumour proliferation by activating the TGF?1?Smad2/3 signalling pathway in colorectal cancer #MMPMID29449642 Lin C; Zhang J; Lu Y; Li X; Zhang W; Zhang W; Lin W; Zheng L; Li X Cell Death Dis 2018[Mar]; 9 (3): ä PMID29449642show ga NIT1 protein has been reported to be a potential tumour suppressor in tumour progression. However, little is known about the specific role of NIT1 in tumour development and progression. In this study, we confirmed the specific effects of NIT1 in the regulation of colorectal carcinoma cell proliferation. Here, we showed that NIT1 was significantly downregulated in colorectal cancer tissues compared with that in adjacent normal tissues. The decreased expression of NIT1 was significantly correlated with poor differentiation and more serosal invasion. Functional experiments showed that NIT1 inhibited CRC cell growth both in vitro and in vivo. NIT1 induced cell cycle arrest and apoptosis. Furthermore, NIT1 recruited Smad2/3 to the TGF? receptor and activated the TGF??Smad2/3 pathway by interacting with SARA and SMAD2/3 in CRC. Further study has shown that SMAD3 directly binds to the promoter regions of NIT1 and enhances the transcription of NIT1. Together, our findings indicate that NIT1 suppresses CRC proliferation through a positive feedback loop between NIT1 and activation of the TGF??Smad signalling pathway. This study might provide a new promising strategy for CRC. äNIT1 suppresses tumour proliferation by activating the TGF?1?Smad2/3 s(epmc).pdf DeepDyve Pubget Overpricing