HOXC8 promotes proliferation and migration through transcriptional up-regulation
of TGF?1 in non-small cell lung cancer
#MMPMID29367650
Liu H
; Zhang M
; Xu S
; Zhang J
; Zou J
; Yang C
; Zhang Y
; Gong C
; Kai Y
; Li Y
Oncogenesis
2018[Jan]; 7
(2
): 1
PMID29367650
show ga
Homeobox (HOX) genes encode a family of transcription factors, which play crucial
roles in numerous processes, and their dysregulation is involved in the
carcinogenesis of many human cancers. In the present study, we investigated the
roles of HOXC8 in non-small cell lung cancer (NSCLC). We showed that HOXC8 was
upregulated in clinical NSCLC specimens compared to normal lung tissues, and the
high expression of HOXC8 correlated with tumor node metastasis (TNM) stage, tumor
status, lymph nodal status and poor relapse-free survival for lung cancer
patients. Functionally, HOXC8 expression significantly promoted the
proliferation, anchorage-independent growth and migration of NSCLC, and HOXC8
functioned as a transcription activator to induce the expression of TGF?1,
leading to an increase in the proliferation, anchorage-independent growth and
migration of NSCLC. Furthermore, we demonstrated that HOXC8 expression was
associated with chemoresistance and anti-apoptosis in NSCLC, suggesting that
HOXC8 is a promising therapeutic target for chemosensitization of NSCLC to
cisplatin. Altogether, our study defined a critical role of HOXC8 in promoting
transcription of TGF?1 and NSCLC tumorigenesis.
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