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10.1038/s41419-018-0367-6 http://scihub22266oqcxt.onion/10.1038/s41419-018-0367-6 C5833500!5833500!29476053     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2018 ; 9 (3): ä Nephropedia Template TP {{tp|p=29476053|t=2018. TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1? axis and indicates prognosis in pancreatic cancer |pdf=|usr=}}{{29476053}} gab.com Text TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1 axis and indicates prognosis in pancreatic cancer JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29476053 #FOAvip Patients with pancreatic ductal adenocarcinoma have much worse prognoses, and much effort has been directed toward understanding the molecular biological aspects of this disease. Accumulated evidence suggests that constitutive activation of the Wnt/?-catenin signalling contributes to the oncogenesis and progression of pancreatic cancer. Transcription factor 7-like2/transcription factor 4 (TCF7L2/TCF4), a ?-catenin transcriptional partner, plays a vital role in the Wnt/?-catenin signalling pathway. In the present study, we investigated the clinicopathological significance of TCF7L2 in pancreatic cancer. Our results demonstrated that patients with higher TCF7L2 expression had worse prognosis. Our in vitro studies demonstrated that TCF7L2 positively regulated aerobic glycolysis by suppressing Egl-9 family hypoxia inducible factor 2 (EGLN2), leading to upregulation of hypoxia inducible factor 1 alpha subunit (HIF-1?). The impact of TCF7L2 on aerobic glycolysis was further confirmed in vivo by assessing 18FDG uptake in pancreatic cancer patients and in a subcutaneous xenograft mouse model. In summary, we identified novel predictive markers for prognosis and suggest a previously unrecognized role for TCF7L2 in control of aerobic glycolysis in pancreatic cancer. Twit Text FOAVip TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1 axis and indicates prognosis in pancreatic cancer ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29476053 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29476053 #FOAvip English Wikipedia <ref>{{Cite pmid|29476053}}</ref> TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1? axis and indicates prognosis in pancreatic cancer #MMPMID29476053 Xiang J; Hu Q; Qin Y; Ji S; Xu W; Liu W; Shi S; Liang C; Liu J; Meng Q; Liang D; Ni Q; Xu J; Zhang B; Yu X Cell Death Dis 2018[Mar]; 9 (3): ä PMID29476053show ga Patients with pancreatic ductal adenocarcinoma have much worse prognoses, and much effort has been directed toward understanding the molecular biological aspects of this disease. Accumulated evidence suggests that constitutive activation of the Wnt/?-catenin signalling contributes to the oncogenesis and progression of pancreatic cancer. Transcription factor 7-like2/transcription factor 4 (TCF7L2/TCF4), a ?-catenin transcriptional partner, plays a vital role in the Wnt/?-catenin signalling pathway. In the present study, we investigated the clinicopathological significance of TCF7L2 in pancreatic cancer. Our results demonstrated that patients with higher TCF7L2 expression had worse prognosis. Our in vitro studies demonstrated that TCF7L2 positively regulated aerobic glycolysis by suppressing Egl-9 family hypoxia inducible factor 2 (EGLN2), leading to upregulation of hypoxia inducible factor 1 alpha subunit (HIF-1?). The impact of TCF7L2 on aerobic glycolysis was further confirmed in vivo by assessing 18FDG uptake in pancreatic cancer patients and in a subcutaneous xenograft mouse model. In summary, we identified novel predictive markers for prognosis and suggest a previously unrecognized role for TCF7L2 in control of aerobic glycolysis in pancreatic cancer. äTCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1? ax(epmc).pdf DeepDyve Pubget Overpricing