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10.1038/s41419-017-0089-1 http://scihub22266oqcxt.onion/10.1038/s41419-017-0089-1 C5833441!5833441 !29352139     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29352139 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2018 ; 9 (2 ): 55 Nephropedia Template TP {{tp|p=29352139 |t=2018. Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition |pdf=|usr=}}{{29352139 }} gab.com Text Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29352139 #FOAvip Cellular senescence, which leads to a cell cycle arrest of damaged or dysfunctional cells, is an important mechanism to restrain the malignant progression of cancer cells. Because metabolic changes underlie many cell-fate decisions, it has been suggested that cell metabolism might play key roles in senescence pathways. Here, we show that mitochondrial glutamine metabolism regulates senescence in human pancreatic ductal adenocarcinoma (PDAC) cells. Glutamine deprivation or inhibition of mitochondrial aspartate transaminase (GOT2) results in a profound induction of senescence and a suppression of PDAC growth. Glutamine carbon flow through GOT2 is required to create NADPH and to maintain the cellular redox state. We found that elevated reactive oxygen species levels by GOT2 knockdown lead to the cyclin-dependent kinase inhibitor p27-mediated senescence. Importantly, PDAC cells exhibit distinct dependence on this pathway, whereas knockdown of GOT2 did not induce senescence in non-transformed cells. The essentiality of GOT2 in senescence regulation of PDAC, which is dispensable in their normal counterparts, may have profound implications for the development of strategies to treat these refractory cancers. Twit Text FOAVip Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29352139 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29352139 #FOAvip English Wikipedia <ref>{{Cite pmid|29352139 }}</ref> Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition #MMPMID29352139 Yang S ; Hwang S ; Kim M ; Seo SB ; Lee JH ; Jeong SM Cell Death Dis 2018[Jan]; 9 (2 ): 55 PMID29352139 show ga Cellular senescence, which leads to a cell cycle arrest of damaged or dysfunctional cells, is an important mechanism to restrain the malignant progression of cancer cells. Because metabolic changes underlie many cell-fate decisions, it has been suggested that cell metabolism might play key roles in senescence pathways. Here, we show that mitochondrial glutamine metabolism regulates senescence in human pancreatic ductal adenocarcinoma (PDAC) cells. Glutamine deprivation or inhibition of mitochondrial aspartate transaminase (GOT2) results in a profound induction of senescence and a suppression of PDAC growth. Glutamine carbon flow through GOT2 is required to create NADPH and to maintain the cellular redox state. We found that elevated reactive oxygen species levels by GOT2 knockdown lead to the cyclin-dependent kinase inhibitor p27-mediated senescence. Importantly, PDAC cells exhibit distinct dependence on this pathway, whereas knockdown of GOT2 did not induce senescence in non-transformed cells. The essentiality of GOT2 in senescence regulation of PDAC, which is dispensable in their normal counterparts, may have profound implications for the development of strategies to treat these refractory cancers. |Aspartate Aminotransferases/antagonists & inhibitors/deficiency/*metabolism [MESH] |Carcinoma, Pancreatic Ductal/*metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/physiology [MESH] |Cellular Senescence/physiology [MESH] |Glutamine/deficiency/*metabolism [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Mitochondria/*metabolism [MESH]Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer(epmc).pdf DeepDyve Pubget Overpricing