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10.1038/s41419-017-0159-4 http://scihub22266oqcxt.onion/10.1038/s41419-017-0159-4 C5833411!5833411 !29367724     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29367724 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2018 ; 9 (2 ): 89 Nephropedia Template TP {{tp|p=29367724 |t=2018. Elimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis |pdf=|usr=}}{{29367724 }} gab.com Text Elimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29367724 #FOAvip Cancer side-population (SP) represents a sub-population of stem-like cancer cells that have an important role in drug resistance due to their high expression of the ATP-binding cassette transporter ABCG2 involved in drug export. Auranofin (AF), a clinical drug of gold complex that is used in treatment of rheumatoid arthritis, has been reported inducing tumor antiproliferation. However, whether AF can impact SP cells remains unclear. Our study showed that AF caused a depletion of SP cells and a downregulation of stem cell markers, and impaired their ability to form tumor colonies in vitro and incidence to develop tumors in vivo of lung cancer cells. Reactive oxygen species (ROS) had an important role in mediating AF-induced depletion of SP cells, which could be reversed by antioxidant NAC. Further study revealed that AF could also cause ATP depletion by inhibition of glycolysis. The depletion of cellular ATP might impair the function of ABCG2 pump, leading to increased drug accumulation within the cells and thus enhancing anticancer activity of chemotherapeutic agents such as adriamycin. Synergistic effect of AF and adriamycin was demonstrated both in vitro and in vivo. Simultaneous increase of ROS and inhibition of glycolysis is a novel strategy to eliminate stem-like cancer cells. Combination of AF with adriamycin seems to be promising to enhance therapeutic effectiveness. Twit Text FOAVip Elimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29367724 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29367724 #FOAvip English Wikipedia <ref>{{Cite pmid|29367724 }}</ref> Elimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis #MMPMID29367724 Hou GX ; Liu PP ; Zhang S ; Yang M ; Liao J ; Yang J ; Hu Y ; Jiang WQ ; Wen S ; Huang P Cell Death Dis 2018[Jan]; 9 (2 ): 89 PMID29367724 show ga Cancer side-population (SP) represents a sub-population of stem-like cancer cells that have an important role in drug resistance due to their high expression of the ATP-binding cassette transporter ABCG2 involved in drug export. Auranofin (AF), a clinical drug of gold complex that is used in treatment of rheumatoid arthritis, has been reported inducing tumor antiproliferation. However, whether AF can impact SP cells remains unclear. Our study showed that AF caused a depletion of SP cells and a downregulation of stem cell markers, and impaired their ability to form tumor colonies in vitro and incidence to develop tumors in vivo of lung cancer cells. Reactive oxygen species (ROS) had an important role in mediating AF-induced depletion of SP cells, which could be reversed by antioxidant NAC. Further study revealed that AF could also cause ATP depletion by inhibition of glycolysis. The depletion of cellular ATP might impair the function of ABCG2 pump, leading to increased drug accumulation within the cells and thus enhancing anticancer activity of chemotherapeutic agents such as adriamycin. Synergistic effect of AF and adriamycin was demonstrated both in vitro and in vivo. Simultaneous increase of ROS and inhibition of glycolysis is a novel strategy to eliminate stem-like cancer cells. Combination of AF with adriamycin seems to be promising to enhance therapeutic effectiveness. |Adenosine Triphosphate/metabolism [MESH] |Animals [MESH] |Auranofin/*pharmacology [MESH] |Biomarkers, Tumor/metabolism [MESH] |Carcinogenesis/drug effects/pathology [MESH] |Cell Line, Tumor [MESH] |Deoxyglucose/metabolism [MESH] |Doxorubicin/pharmacology [MESH] |Drug Synergism [MESH] |Glycolysis/*drug effects [MESH] |Hexokinase/metabolism [MESH] |Humans [MESH] |Mice [MESH] |Neoplastic Stem Cells/drug effects/metabolism/*pathology [MESH] |Reactive Oxygen Species/*metabolism [MESH] |Side-Population Cells/drug effects/metabolism/*pathology [MESH] |Spheroids, Cellular/drug effects/metabolism/pathology [MESH]Elimination of stem-like cancer cell side-population by auranofin thro(epmc).pdf DeepDyve Pubget Overpricing