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10.4110/in.2018.18.e1

http://scihub22266oqcxt.onion/10.4110/in.2018.18.e1
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C5833116!5833116!29503736
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suck abstract from ncbi


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pmid29503736      Immune+Netw 2018 ; 18 (1): ä
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  • Control of Innate and Adaptive Lymphocytes by the RAR-Retinoic Acid Axis #MMPMID29503736
  • Kim CH
  • Immune Netw 2018[Feb]; 18 (1): ä PMID29503736show ga
  • Lymphocytes, such as T cells, B cells, and innate lymphoid cells (ILCs), play central roles in regulating immune responses. Retinoic acids (RAs) are vitamin A metabolites, produced and metabolized by certain tissue cells and myeloid cells in a tissue-specific manner. It has been established that RAs induce gut-homing receptors on T cells, B cells, and ILCs. A mounting body of evidence indicates that RAs exert far-reaching effects on functional differentiation and fate of these lymphocytes. For example, RAs promote effector T cell maintenance, generation of induced gut-homing regulatory and effector T cell subsets, antibody production by B cells, and functional maturation of ILCs. Key functions of RAs in regulating major groups of innate and adaptive lymphocytes are highlighted in this article.
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