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10.1016/j.ebiom.2017.11.022 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2017.11.022 C5832640!5832640!29217135     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EBioMedicine 2017 ; 26 (ä): 175-86 Nephropedia Template TP {{tp|p=29217135|t=2017. MicroRNA-145 Impedes Thrombus Formation via Targeting Tissue Factor in Venous Thrombosis |pdf=|usr=}}{{29217135}} gab.com Text MicroRNA-145 Impedes Thrombus Formation via Targeting Tissue Factor in Venous Thrombosis JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=29217135 #FOAvip Venous thromboembolism (VTE), the third leading cardiovascular complication, requires more understanding at molecular levels. Here, we have identified miR-145 as a key molecule for regulating thrombus formation in venous thrombosis (VT) employing network based bioinformatics approach and in vivo experiments. Levels of miR-145 showed an inverse correlation with thrombus load determined by coagulation variables. MiRNA target prediction tools and in vitro study identified tissue factor (TF) as a target gene for miR-145. The restoration of miR-145 levels in thrombotic animals via in vivo miR-145 mimic delivery resulted in decreased TF level and activity, accompanied by reduced thrombogenesis. MiR-145 levels were also reduced in VT patients and correlated with increased TF levels in patients, thereby, confirming our preclinical findings. Our study identifies a previously undescribed role of miRNA in VT by regulating TF expression. Therefore, restoration of miR-145 levels may serve as a promising therapeutic strategy for management of VT. Twit Text FOAVip MicroRNA-145 Impedes Thrombus Formation via Targeting Tissue Factor in Venous Thrombosis ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=29217135 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29217135 #FOAvip English Wikipedia <ref>{{Cite pmid|29217135}}</ref> MicroRNA-145 Impedes Thrombus Formation via Targeting Tissue Factor in Venous Thrombosis #MMPMID29217135 Sahu A; Jha PK; Prabhakar A; Singh HD; Gupta N; Chatterjee T; Tyagi T; Sharma S; Kumari B; Singh S; Nair V; Goel S; Ashraf MZ EBioMedicine 2017[Dec]; 26 (ä): 175-86 PMID29217135show ga Venous thromboembolism (VTE), the third leading cardiovascular complication, requires more understanding at molecular levels. Here, we have identified miR-145 as a key molecule for regulating thrombus formation in venous thrombosis (VT) employing network based bioinformatics approach and in vivo experiments. Levels of miR-145 showed an inverse correlation with thrombus load determined by coagulation variables. MiRNA target prediction tools and in vitro study identified tissue factor (TF) as a target gene for miR-145. The restoration of miR-145 levels in thrombotic animals via in vivo miR-145 mimic delivery resulted in decreased TF level and activity, accompanied by reduced thrombogenesis. MiR-145 levels were also reduced in VT patients and correlated with increased TF levels in patients, thereby, confirming our preclinical findings. Our study identifies a previously undescribed role of miRNA in VT by regulating TF expression. Therefore, restoration of miR-145 levels may serve as a promising therapeutic strategy for management of VT. äMicroRNA-145 Impedes Thrombus Formation via Targeting Tissue Factor in(epmc).pdf DeepDyve Pubget Overpricing