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10.1111/1759-7714.12584 http://scihub22266oqcxt.onion/10.1111/1759-7714.12584 C5832475!5832475!29316252     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Thorac+Cancer 2018 ; 9 (3): 353-9 Nephropedia Template TP {{tp|p=29316252|t=2018. Manganese?12 acetate suppresses the migration, invasion, and epithelial?mesenchymal transition by inhibiting Wnt/??catenin and PI3K/AKT signaling pathways in breast cancer cells |pdf=|usr=}}{{29316252}} gab.com Text Manganese 12 acetate suppresses the migration, invasion, and epithelial mesenchymal transition by inhibiting Wnt/ catenin and PI3K/AKT signaling pathways in breast cancer cells JO: Thorac Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29316252 #FOAvip Background: Breast cancer is the leading cause of cancer?related death in the world, and it is of great value to reveal the molecular mechanisms of breast cancer progression and develop new therapeutic targets. Methods: Transwell assay is used to analyze the migration and invasion of breast cancer cells. Real?time PCR and western blotting assay are applied to detect the expression levels of epithelial?mesenchymal transition markers and the key members of Wnt/??catenin and PI3K/AKT signaling pathways. Results: Manganese?12 acetate (Mn12Ac) significantly inhibited the migration and invasion of MCF7 and MDA?MB?231 breast cancer cells. Western blotting assay further showed that Mn12Ac significantly upregulated E?cadherin, and downregulated N?cadherin and vimentin. We further found that Mn12Ac reduced the mRNA expressions of epithelial?mesenchymal transition?associated transcription factors snail, slug, twist1, and ZEB1 using real?time PCR assay. Importantly, we further found that Mn12Ac significantly reduced the Wnt1 and ??catenin protein expressions, and suppressed the phosphorylation of PI3K and AKT in MCF7 and MDA?MB?231 breast cancer cells. Very interestingly, we also showed that Mn12Ac decreased the mRNA and protein expressions of programmed cell death ligand 1. Conclusion: Taken together, our results suggested that Mn12Ac inhibited the migration, invasion, and epithelial?mesenchymal transition by regulating Wnt/??catenin and PI3K/AKT signaling pathways in breast cancer. Twit Text FOAVip Manganese 12 acetate suppresses the migration, invasion, and epithelial mesenchymal transition by inhibiting Wnt/ catenin and PI3K/AKT signaling pathways in breast cancer cells ????Thorac Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29316252 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29316252 #FOAvip English Wikipedia <ref>{{Cite pmid|29316252}}</ref> Manganese?12 acetate suppresses the migration, invasion, and epithelial?mesenchymal transition by inhibiting Wnt/??catenin and PI3K/AKT signaling pathways in breast cancer cells #MMPMID29316252 Ju H; Li Y; Xing X; Miao X; Feng Y; Ren Y; Qin J; Liu D; Chen Z; Yang Z Thorac Cancer 2018[Mar]; 9 (3): 353-9 PMID29316252show ga Background: Breast cancer is the leading cause of cancer?related death in the world, and it is of great value to reveal the molecular mechanisms of breast cancer progression and develop new therapeutic targets. Methods: Transwell assay is used to analyze the migration and invasion of breast cancer cells. Real?time PCR and western blotting assay are applied to detect the expression levels of epithelial?mesenchymal transition markers and the key members of Wnt/??catenin and PI3K/AKT signaling pathways. Results: Manganese?12 acetate (Mn12Ac) significantly inhibited the migration and invasion of MCF7 and MDA?MB?231 breast cancer cells. Western blotting assay further showed that Mn12Ac significantly upregulated E?cadherin, and downregulated N?cadherin and vimentin. We further found that Mn12Ac reduced the mRNA expressions of epithelial?mesenchymal transition?associated transcription factors snail, slug, twist1, and ZEB1 using real?time PCR assay. Importantly, we further found that Mn12Ac significantly reduced the Wnt1 and ??catenin protein expressions, and suppressed the phosphorylation of PI3K and AKT in MCF7 and MDA?MB?231 breast cancer cells. Very interestingly, we also showed that Mn12Ac decreased the mRNA and protein expressions of programmed cell death ligand 1. Conclusion: Taken together, our results suggested that Mn12Ac inhibited the migration, invasion, and epithelial?mesenchymal transition by regulating Wnt/??catenin and PI3K/AKT signaling pathways in breast cancer. äManganese?12 acetate suppresses the migration, invasion, and epithelia(epmc).pdf DeepDyve Pubget Overpricing