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10.1111/1759-7714.12584 http://scihub22266oqcxt.onion/10.1111/1759-7714.12584 C5832475!5832475 !29316252     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29316252 &cmd=llinks): Failed to open stream: HTTP request failed! 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Manganese-12 acetate suppresses the migration, invasion, and epithelial-mesenchymal transition by inhibiting Wnt/?-catenin and PI3K/AKT signaling pathways in breast cancer cells |pdf=|usr=}}{{29316252 }} gab.com Text Manganese-12 acetate suppresses the migration, invasion, and epithelial-mesenchymal transition by inhibiting Wnt/ -catenin and PI3K/AKT signaling pathways in breast cancer cells JO: Thorac Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29316252 #FOAvip BACKGROUND: Breast cancer is the leading cause of cancer-related death in the world, and it is of great value to reveal the molecular mechanisms of breast cancer progression and develop new therapeutic targets. METHODS: Transwell assay is used to analyze the migration and invasion of breast cancer cells. Real-time PCR and western blotting assay are applied to detect the expression levels of epithelial-mesenchymal transition markers and the key members of Wnt/?-catenin and PI3K/AKT signaling pathways. RESULTS: Manganese-12 acetate (Mn12Ac) significantly inhibited the migration and invasion of MCF7 and MDA-MB-231 breast cancer cells. Western blotting assay further showed that Mn12Ac significantly upregulated E-cadherin, and downregulated N-cadherin and vimentin. We further found that Mn12Ac reduced the mRNA expressions of epithelial-mesenchymal transition-associated transcription factors snail, slug, twist1, and ZEB1 using real-time PCR assay. Importantly, we further found that Mn12Ac significantly reduced the Wnt1 and ?-catenin protein expressions, and suppressed the phosphorylation of PI3K and AKT in MCF7 and MDA-MB-231 breast cancer cells. Very interestingly, we also showed that Mn12Ac decreased the mRNA and protein expressions of programmed cell death ligand 1. CONCLUSION: Taken together, our results suggested that Mn12Ac inhibited the migration, invasion, and epithelial-mesenchymal transition by regulating Wnt/?-catenin and PI3K/AKT signaling pathways in breast cancer. Twit Text FOAVip Manganese-12 acetate suppresses the migration, invasion, and epithelial-mesenchymal transition by inhibiting Wnt/ -catenin and PI3K/AKT signaling pathways in breast cancer cells ????Thorac Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29316252 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29316252 #FOAvip English Wikipedia <ref>{{Cite pmid|29316252 }}</ref> Manganese-12 acetate suppresses the migration, invasion, and epithelial-mesenchymal transition by inhibiting Wnt/?-catenin and PI3K/AKT signaling pathways in breast cancer cells #MMPMID29316252 Ju H ; Li Y ; Xing X ; Miao X ; Feng Y ; Ren Y ; Qin J ; Liu D ; Chen Z ; Yang Z Thorac Cancer 2018[Mar]; 9 (3 ): 353-359 PMID29316252 show ga BACKGROUND: Breast cancer is the leading cause of cancer-related death in the world, and it is of great value to reveal the molecular mechanisms of breast cancer progression and develop new therapeutic targets. METHODS: Transwell assay is used to analyze the migration and invasion of breast cancer cells. Real-time PCR and western blotting assay are applied to detect the expression levels of epithelial-mesenchymal transition markers and the key members of Wnt/?-catenin and PI3K/AKT signaling pathways. RESULTS: Manganese-12 acetate (Mn12Ac) significantly inhibited the migration and invasion of MCF7 and MDA-MB-231 breast cancer cells. Western blotting assay further showed that Mn12Ac significantly upregulated E-cadherin, and downregulated N-cadherin and vimentin. We further found that Mn12Ac reduced the mRNA expressions of epithelial-mesenchymal transition-associated transcription factors snail, slug, twist1, and ZEB1 using real-time PCR assay. Importantly, we further found that Mn12Ac significantly reduced the Wnt1 and ?-catenin protein expressions, and suppressed the phosphorylation of PI3K and AKT in MCF7 and MDA-MB-231 breast cancer cells. Very interestingly, we also showed that Mn12Ac decreased the mRNA and protein expressions of programmed cell death ligand 1. CONCLUSION: Taken together, our results suggested that Mn12Ac inhibited the migration, invasion, and epithelial-mesenchymal transition by regulating Wnt/?-catenin and PI3K/AKT signaling pathways in breast cancer. |Antineoplastic Agents/*pharmacology [MESH] |Breast Neoplasms/*pathology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Female [MESH] |Humans [MESH] |Manganese Compounds/*pharmacology [MESH] |Phosphatidylinositol 3-Kinases/drug effects [MESH] |Proto-Oncogene Proteins c-akt/drug effects [MESH] |Signal Transduction/*drug effects [MESH]Manganese-12 acetate suppresses the migration, invasion, and epithel(epmc).pdf DeepDyve Pubget Overpricing