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10.1038/s41419-017-0179-0 http://scihub22266oqcxt.onion/10.1038/s41419-017-0179-0 C5832420!5832420 !29491433     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29491433 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2018 ; 9 (3 ): 334 Nephropedia Template TP {{tp|p=29491433 |t=2018. Emerging molecular mechanisms in chemotherapy: Ca(2+) signaling at the mitochondria-associated endoplasmic reticulum membranes |pdf=|usr=}}{{29491433 }} gab.com Text Emerging molecular mechanisms in chemotherapy: Ca(2+) signaling at the mitochondria-associated endoplasmic reticulum membranes JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29491433 #FOAvip Inter-organellar communication often takes the form of Ca(2+) signals. These Ca(2+) signals originate from the endoplasmic reticulum (ER) and regulate different cellular processes like metabolism, fertilization, migration, and cell fate. A prime target for Ca(2+) signals are the mitochondria. ER-mitochondrial Ca(2+) transfer is possible through the existence of mitochondria-associated ER membranes (MAMs), ER structures that are in the proximity of the mitochondria. This creates a micro-domain in which the Ca(2+) concentrations are manifold higher than in the cytosol, allowing for rapid mitochondrial Ca(2+) uptake. In the mitochondria, the Ca(2+) signal is decoded differentially depending on its spatiotemporal characteristics. While Ca(2+) oscillations stimulate metabolism and constitute pro-survival signaling, mitochondrial Ca(2+) overload results in apoptosis. Many chemotherapeutics depend on efficient ER-mitochondrial Ca(2+) signaling to exert their function. However, several oncogenes and tumor suppressors present in the MAMs can alter Ca(2+) signaling in cancer cells, rendering chemotherapeutics ineffective. In this review, we will discuss recent studies that connect ER-mitochondrial Ca(2+) transfer, tumor suppressors and oncogenes at the MAMs, and chemotherapy. Twit Text FOAVip Emerging molecular mechanisms in chemotherapy: Ca(2+) signaling at the mitochondria-associated endoplasmic reticulum membranes ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29491433 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29491433 #FOAvip English Wikipedia <ref>{{Cite pmid|29491433 }}</ref> Emerging molecular mechanisms in chemotherapy: Ca(2+) signaling at the mitochondria-associated endoplasmic reticulum membranes #MMPMID29491433 Kerkhofs M ; Bittremieux M ; Morciano G ; Giorgi C ; Pinton P ; Parys JB ; Bultynck G Cell Death Dis 2018[Feb]; 9 (3 ): 334 PMID29491433 show ga Inter-organellar communication often takes the form of Ca(2+) signals. These Ca(2+) signals originate from the endoplasmic reticulum (ER) and regulate different cellular processes like metabolism, fertilization, migration, and cell fate. A prime target for Ca(2+) signals are the mitochondria. ER-mitochondrial Ca(2+) transfer is possible through the existence of mitochondria-associated ER membranes (MAMs), ER structures that are in the proximity of the mitochondria. This creates a micro-domain in which the Ca(2+) concentrations are manifold higher than in the cytosol, allowing for rapid mitochondrial Ca(2+) uptake. In the mitochondria, the Ca(2+) signal is decoded differentially depending on its spatiotemporal characteristics. While Ca(2+) oscillations stimulate metabolism and constitute pro-survival signaling, mitochondrial Ca(2+) overload results in apoptosis. Many chemotherapeutics depend on efficient ER-mitochondrial Ca(2+) signaling to exert their function. However, several oncogenes and tumor suppressors present in the MAMs can alter Ca(2+) signaling in cancer cells, rendering chemotherapeutics ineffective. In this review, we will discuss recent studies that connect ER-mitochondrial Ca(2+) transfer, tumor suppressors and oncogenes at the MAMs, and chemotherapy. |*Calcium Signaling [MESH] |Animals [MESH] |Antineoplastic Agents/*metabolism/therapeutic use [MESH] |Calcium/metabolism [MESH] |Endoplasmic Reticulum/genetics/*metabolism [MESH] |Humans [MESH] |Mitochondria/genetics/*metabolism [MESH] |Mitochondrial Membranes/*metabolism [MESH]Emerging molecular mechanisms in chemotherapy: Ca(2+) signaling at the(epmc).pdf DeepDyve Pubget Overpricing