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2018 ; 12
(2
): 165-172
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gab.com Text
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Clinical Outcomes of Standard Triple Therapy Plus Probiotics or Concomitant
Therapy for Helicobacter pylori Infection
#MMPMID29212313
Jung JH
; Cho IK
; Lee CH
; Song GG
; Lim JH
Gut Liver
2018[Mar]; 12
(2
): 165-172
PMID29212313
show ga
BACKGROUND/AIMS: The efficacy of standard triple therapy (STT) in treating
Helicobacter pylori infection has decreased. Many investigators have attempted to
increase the eradication rate. We investigated the outcomes of concomitant
therapy (CT) and STT combined with probiotics (STP) as a first-line treatment for
H. pylori infection. METHODS: We reviewed the medical records of 361 patients who
received either STP (n=286) or CT (n=75). The STP group received STT combined
with a probiotic preparation for 1 week. The CT group received STT and
metronidazole for 1 week. RESULTS: The intention-to-treat and per-protocol
eradication rates were 83.6% (95% confidence interval [CI], 79.0 to 87.7) and
87.1% (95% CI, 81.2 to 89.7) in the STP group and 86.7% (95% CI, 78.7 to 93.3)
and 91.4% (95% CI, 83.6 to 97.1) in the CT group (p=0.512 and p=0.324),
respectively. The frequency of adverse effects was higher in the CT group (28.2%)
than in the STP group (12.8%) (p=0.002). CONCLUSIONS: STP and CT are
encouragingly efficacious as first-line treatments for H. pylori infection.
Therefore, adding probiotics to STT may be a feasible option to avoid side
effects.