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10.1155/2018/9524657 http://scihub22266oqcxt.onion/10.1155/2018/9524657 C5832143!5832143 !29643980     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29643980 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oxid+Med+Cell+Longev 2018 ; 2018 (ä): 9524657 Nephropedia Template TP {{tp|p=29643980 |t=2018. Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes |pdf=|usr=}}{{29643980 }} gab.com Text Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes JO: Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=29643980 #FOAvip The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediated by the nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase-1 (HO1) axis in human keratinocytes. Perillaldehyde is the main component of Perilla frutescens, which is a medicinal antioxidant herb traditionally consumed in East Asia. However, the effect of perillaldehyde on the AHR/ROS and/or NRF2/HO1 pathways remains unknown. In human keratinocytes, we found that perillaldehyde (1) inhibited BaP-induced AHR activation and ROS production, (2) inhibited BaP/AHR-mediated release of the CCL2 chemokine, and (3) activated the NRF2/HO1 antioxidant pathway. Perillaldehyde is thus potentially useful for managing inflammatory skin diseases or disorders related to oxidative stress. Twit Text FOAVip Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes ????Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=29643980 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29643980 #FOAvip English Wikipedia <ref>{{Cite pmid|29643980 }}</ref> Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes #MMPMID29643980 Fuyuno Y ; Uchi H ; Yasumatsu M ; Morino-Koga S ; Tanaka Y ; Mitoma C ; Furue M Oxid Med Cell Longev 2018[]; 2018 (ä): 9524657 PMID29643980 show ga The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediated by the nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase-1 (HO1) axis in human keratinocytes. Perillaldehyde is the main component of Perilla frutescens, which is a medicinal antioxidant herb traditionally consumed in East Asia. However, the effect of perillaldehyde on the AHR/ROS and/or NRF2/HO1 pathways remains unknown. In human keratinocytes, we found that perillaldehyde (1) inhibited BaP-induced AHR activation and ROS production, (2) inhibited BaP/AHR-mediated release of the CCL2 chemokine, and (3) activated the NRF2/HO1 antioxidant pathway. Perillaldehyde is thus potentially useful for managing inflammatory skin diseases or disorders related to oxidative stress. |Antioxidants/metabolism [MESH] |Basic Helix-Loop-Helix Transcription Factors/*antagonists & inhibitors/metabolism [MESH] |Benzo(a)pyrene/pharmacology [MESH] |Cell Line [MESH] |Cell Nucleus/drug effects/metabolism [MESH] |Cell Survival/drug effects [MESH] |Chemokine CCL2/biosynthesis [MESH] |Cytochrome P-450 CYP1A1/antagonists & inhibitors/biosynthesis [MESH] |Heme Oxygenase-1/antagonists & inhibitors/metabolism [MESH] |Humans [MESH] |Keratinocytes/cytology/*drug effects/metabolism [MESH] |Monoterpenes/*pharmacology [MESH] |NF-E2-Related Factor 2/*metabolism [MESH] |Reactive Oxygen Species/antagonists & inhibitors/metabolism [MESH] |Receptors, Aryl Hydrocarbon/*antagonists & inhibitors/metabolism [MESH]Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant P(epmc).pdf DeepDyve Pubget Overpricing