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10.3390/ncrna3030022 http://scihub22266oqcxt.onion/10.3390/ncrna3030022 C5831915!5831915!29657293     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Noncoding+RNA 2017 ; 3 (3): ä Nephropedia Template TP {{tp|p=29657293|t=2017. miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development |pdf=|usr=}}{{29657293}} gab.com Text miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development JO: Noncoding RNA http://www.kidney.de/pget.php?&tw=1&pmid=29657293 #FOAvip MicroRNAs (miRNAs or miRs) are a class of evolutionarily-conserved small, regulatory non-coding RNAs, 19?3 nucleotides in length, that negatively regulate protein coding gene transcripts? expression. miR-146 (146a and 146b) and miR-155 are among the first and most studied miRs for their multiple roles in the control of the innate and adaptive immune processes and for their deregulation and oncogenic role in some tumors. In the present review, we have focused on the recent acquisitions about the key role played by miR-146a, miR-146b and miR-155 in the control of the immune system and in myeloid tumorigenesis. Growing experimental evidence indicates an opposite role of miR-146a with respect to miR-155 in the fine regulation of many steps of the immune response, acting at the level of the various cell types involved in innate and adaptive immune mechanisms. The demonstration that miR-155 overexpression plays a key pathogenic role in some lymphomas and acute myeloid leukemias has led to the development of an antagomir-based approach as a new promising therapeutic strategy. Twit Text FOAVip miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development ????Noncoding RNA http://www.kidney.de/pget.php?&tw=1&pmid=29657293 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29657293 #FOAvip English Wikipedia <ref>{{Cite pmid|29657293}}</ref> miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development #MMPMID29657293 Testa U; Pelosi E; Castelli G; Labbaye C Noncoding RNA 2017[Sep]; 3 (3): ä PMID29657293show ga MicroRNAs (miRNAs or miRs) are a class of evolutionarily-conserved small, regulatory non-coding RNAs, 19?3 nucleotides in length, that negatively regulate protein coding gene transcripts? expression. miR-146 (146a and 146b) and miR-155 are among the first and most studied miRs for their multiple roles in the control of the innate and adaptive immune processes and for their deregulation and oncogenic role in some tumors. In the present review, we have focused on the recent acquisitions about the key role played by miR-146a, miR-146b and miR-155 in the control of the immune system and in myeloid tumorigenesis. Growing experimental evidence indicates an opposite role of miR-146a with respect to miR-155 in the fine regulation of many steps of the immune response, acting at the level of the various cell types involved in innate and adaptive immune mechanisms. The demonstration that miR-155 overexpression plays a key pathogenic role in some lymphomas and acute myeloid leukemias has led to the development of an antagomir-based approach as a new promising therapeutic strategy. ämiR-146 and miR-155: Two Key Modulators of Immune Response and Tumor D(epmc).pdf DeepDyve Pubget Overpricing