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10.3390/jdb4040034 http://scihub22266oqcxt.onion/10.3390/jdb4040034 C5831803/?report=reader!5831803!29615597     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Dev+Biol 2016 ; 4 (4): ä Nephropedia Template TP {{tp|p=29615597|t=2016. Perspectives on Intra- and Intercellular Trafficking of Hedgehog for Tissue Patterning |pdf=|usr=}}{{29615597}} gab.com Text Perspectives on Intra- and Intercellular Trafficking of Hedgehog for Tissue Patterning JO: J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=29615597 #FOAvip Intercellular communication is a fundamental process for correct tissue development. The mechanism of this process involves, among other things, the production and secretion of signaling molecules by specialized cell types and the capability of these signals to reach the target cells in order to trigger specific responses. Hedgehog (Hh) is one of the best-studied signaling pathways because of its importance during morphogenesis in many organisms. The Hh protein acts as a morphogen, activating its targets at a distance in a concentration-dependent manner. Post-translational modifications of Hh lead to a molecule covalently bond to two lipid moieties. These lipid modifications confer Hh high affinity to lipidic membranes, and intense studies have been carried out to explain its release into the extracellular matrix. This work reviews Hh molecule maturation, the intracellular recycling needed for its secretion and the proposed carriers to explain Hh transportation to the receiving cells. Special focus is placed on the role of specialized filopodia, also named cytonemes, in morphogen transport and gradient formation. Twit Text FOAVip Perspectives on Intra- and Intercellular Trafficking of Hedgehog for Tissue Patterning ????J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=29615597 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29615597 #FOAvip English Wikipedia <ref>{{Cite pmid|29615597}}</ref> Perspectives on Intra- and Intercellular Trafficking of Hedgehog for Tissue Patterning #MMPMID29615597 Simon E; Aguirre-Tamaral A; Aguilar G; Guerrero I J Dev Biol 2016[Dec]; 4 (4): ä PMID29615597show ga Intercellular communication is a fundamental process for correct tissue development. The mechanism of this process involves, among other things, the production and secretion of signaling molecules by specialized cell types and the capability of these signals to reach the target cells in order to trigger specific responses. Hedgehog (Hh) is one of the best-studied signaling pathways because of its importance during morphogenesis in many organisms. The Hh protein acts as a morphogen, activating its targets at a distance in a concentration-dependent manner. Post-translational modifications of Hh lead to a molecule covalently bond to two lipid moieties. These lipid modifications confer Hh high affinity to lipidic membranes, and intense studies have been carried out to explain its release into the extracellular matrix. This work reviews Hh molecule maturation, the intracellular recycling needed for its secretion and the proposed carriers to explain Hh transportation to the receiving cells. Special focus is placed on the role of specialized filopodia, also named cytonemes, in morphogen transport and gradient formation. äPerspectives on Intra- and Intercellular Trafficking of Hedgehog for T(epmc).pdf DeepDyve Pubget Overpricing