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10.3390/jdb4040036 http://scihub22266oqcxt.onion/10.3390/jdb4040036 C5831800/?report=reader!5831800!29615599     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Dev+Biol 2016 ; 4 (4): ä Nephropedia Template TP {{tp|p=29615599|t=2016. Differential Cellular Responses to Hedgehog Signalling in Vertebrates?What is the Role of Competence?|pdf=|usr=}}{{29615599}} gab.com Text Differential Cellular Responses to Hedgehog Signalling in Vertebrates What is the Role of Competence JO: J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=29615599 #FOAvip A surprisingly small number of signalling pathways generate a plethora of cellular responses ranging from the acquisition of multiple cell fates to proliferation, differentiation, morphogenesis and cell death. These diverse responses may be due to the dose-dependent activities of signalling factors, or to intrinsic differences in the response of cells to a given signal?a phenomenon called differential cellular competence. In this review, we focus on temporal and spatial differences in competence for Hedgehog (HH) signalling, a signalling pathway that is reiteratively employed in embryos and adult organisms. We discuss the upstream signals and mechanisms that may establish differential competence for HHs in a range of different tissues. We argue that the changing competence for HH signalling provides a four-dimensional framework for the interpretation of the signal that is essential for the emergence of functional anatomy. A number of diseases?including several types of cancer?are caused by malfunctions of the HH pathway. A better understanding of what provides differential competence for this signal may reveal HH-related disease mechanisms and equip us with more specific tools to manipulate HH signalling in the clinic. Twit Text FOAVip Differential Cellular Responses to Hedgehog Signalling in Vertebrates What is the Role of Competence ????J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=29615599 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29615599 #FOAvip English Wikipedia <ref>{{Cite pmid|29615599}}</ref> Differential Cellular Responses to Hedgehog Signalling in Vertebrates?What is the Role of Competence? #MMPMID29615599 Kiecker C; Graham A; Logan M J Dev Biol 2016[Dec]; 4 (4): ä PMID29615599show ga A surprisingly small number of signalling pathways generate a plethora of cellular responses ranging from the acquisition of multiple cell fates to proliferation, differentiation, morphogenesis and cell death. These diverse responses may be due to the dose-dependent activities of signalling factors, or to intrinsic differences in the response of cells to a given signal?a phenomenon called differential cellular competence. In this review, we focus on temporal and spatial differences in competence for Hedgehog (HH) signalling, a signalling pathway that is reiteratively employed in embryos and adult organisms. We discuss the upstream signals and mechanisms that may establish differential competence for HHs in a range of different tissues. We argue that the changing competence for HH signalling provides a four-dimensional framework for the interpretation of the signal that is essential for the emergence of functional anatomy. A number of diseases?including several types of cancer?are caused by malfunctions of the HH pathway. A better understanding of what provides differential competence for this signal may reveal HH-related disease mechanisms and equip us with more specific tools to manipulate HH signalling in the clinic. äDifferential Cellular Responses to Hedgehog Signalling in Vertebrates?(epmc).pdf DeepDyve Pubget Overpricing