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10.3390/jdb5040013 http://scihub22266oqcxt.onion/10.3390/jdb5040013 C5831797/?report=reader!5831797!29615569     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Dev+Biol 2017 ; 5 (4): ä Nephropedia Template TP {{tp|p=29615569|t=2017. Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control |pdf=|usr=}}{{29615569}} gab.com Text Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control JO: J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=29615569 #FOAvip Hedgehog (Hh)/GLI signaling is an important instructive cue in various processes during embryonic development, such as tissue patterning, stem cell maintenance, and cell differentiation. It also plays crucial roles in the development of many pediatric and adult malignancies. Understanding the molecular mechanisms of pathway regulation is therefore of high interest. Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) comprise a group of protein kinases which are emerging modulators of signal transduction, cell proliferation, survival, and cell differentiation. Work from the last years has identified a close regulatory connection between DYRKs and the Hh signaling system. In this manuscript, we outline the mechanistic influence of DYRK kinases on Hh signaling with a focus on the mammalian situation. We furthermore aim to bring together what is known about the functional consequences of a DYRK-Hh cross-talk and how this might affect cellular processes in development, physiology, and pathology. Twit Text FOAVip Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control ????J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=29615569 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29615569 #FOAvip English Wikipedia <ref>{{Cite pmid|29615569}}</ref> Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control #MMPMID29615569 Singh R; Lauth M J Dev Biol 2017[Dec]; 5 (4): ä PMID29615569show ga Hedgehog (Hh)/GLI signaling is an important instructive cue in various processes during embryonic development, such as tissue patterning, stem cell maintenance, and cell differentiation. It also plays crucial roles in the development of many pediatric and adult malignancies. Understanding the molecular mechanisms of pathway regulation is therefore of high interest. Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) comprise a group of protein kinases which are emerging modulators of signal transduction, cell proliferation, survival, and cell differentiation. Work from the last years has identified a close regulatory connection between DYRKs and the Hh signaling system. In this manuscript, we outline the mechanistic influence of DYRK kinases on Hh signaling with a focus on the mammalian situation. We furthermore aim to bring together what is known about the functional consequences of a DYRK-Hh cross-talk and how this might affect cellular processes in development, physiology, and pathology. äEmerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway C(epmc).pdf DeepDyve Pubget Overpricing