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10.3390/jdb4030027 http://scihub22266oqcxt.onion/10.3390/jdb4030027 C5831775/?report=reader!5831775!29615591     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Dev+Biol 2016 ; 4 (3): ä Nephropedia Template TP {{tp|p=29615591|t=2016. Control of Hedgehog Signalling by the Cilia-Regulated Proteasome |pdf=|usr=}}{{29615591}} gab.com Text Control of Hedgehog Signalling by the Cilia-Regulated Proteasome JO: J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=29615591 #FOAvip The Hedgehog signalling pathway is evolutionarily highly conserved and essential for embryonic development of invertebrates and vertebrates. Consequently, impaired Hedgehog signalling results in very severe human diseases, ranging from holoprosencephaly to Pallister-Hall syndrome. Due to this great importance for human health, the focus of numerous research groups is placed on the investigation of the detailed mechanisms underlying Hedgehog signalling. Today, it is known that tiny cell protrusions, known as primary cilia, are necessary to mediate Hedgehog signalling in vertebrates. Although the Hedgehog pathway is one of the best studied signalling pathways, many questions remain. One of these questions is: How do primary cilia control Hedgehog signalling in vertebrates? Recently, it was shown that primary cilia regulate a special kind of proteasome which is essential for proper Hedgehog signalling. This review article will cover this novel cilia-proteasome association in embryonic Hedgehog signalling and discuss the possibilities provided by future investigations on this topic. Twit Text FOAVip Control of Hedgehog Signalling by the Cilia-Regulated Proteasome ????J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=29615591 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29615591 #FOAvip English Wikipedia <ref>{{Cite pmid|29615591}}</ref> Control of Hedgehog Signalling by the Cilia-Regulated Proteasome #MMPMID29615591 Gerhardt C; Wiegering A; Leu T; Rüther U J Dev Biol 2016[Sep]; 4 (3): ä PMID29615591show ga The Hedgehog signalling pathway is evolutionarily highly conserved and essential for embryonic development of invertebrates and vertebrates. Consequently, impaired Hedgehog signalling results in very severe human diseases, ranging from holoprosencephaly to Pallister-Hall syndrome. Due to this great importance for human health, the focus of numerous research groups is placed on the investigation of the detailed mechanisms underlying Hedgehog signalling. Today, it is known that tiny cell protrusions, known as primary cilia, are necessary to mediate Hedgehog signalling in vertebrates. Although the Hedgehog pathway is one of the best studied signalling pathways, many questions remain. One of these questions is: How do primary cilia control Hedgehog signalling in vertebrates? Recently, it was shown that primary cilia regulate a special kind of proteasome which is essential for proper Hedgehog signalling. This review article will cover this novel cilia-proteasome association in embryonic Hedgehog signalling and discuss the possibilities provided by future investigations on this topic. äControl of Hedgehog Signalling by the Cilia-Regulated Proteasome (epmc).pdf DeepDyve Pubget Overpricing