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10.3390/jdb4030028 http://scihub22266oqcxt.onion/10.3390/jdb4030028 C5831774/?report=reader!5831774!29615592     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Dev+Biol 2016 ; 4 (3): ä Nephropedia Template TP {{tp|p=29615592|t=2016. Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage |pdf=|usr=}}{{29615592}} gab.com Text Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage JO: J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=29615592 #FOAvip The Hedgehog morphogen aroused an enormous interest since it was characterized as an essential signal for ventral patterning of the spinal cord two decades ago. The pathway is notably implicated in the initial appearance of the progenitors of oligodendrocytes (OPCs), the glial cells of the central nervous system which after maturation are responsible for axon myelination. In accordance with the requirement for Hedgehog signaling in ventral patterning, the earliest identifiable cells in the oligodendrocyte lineage are derived from the ventral ventricular zone of the developing spinal cord and brain. Here, we present the current knowledge about the involvement of Hedgehog signaling in the strict spatial and temporal regulation which characterizes the initiation and progression of the oligodendrocyte lineage. We notably describe the ability of the Hedgehog signaling to tightly orchestrate the appearance of specific combinations of genes in concert with other pathways. We document the molecular mechanisms controlling Hedgehog temporal activity during OPC specification. The contribution of the pathway to aspects of OPC development different from their specification is also highlighted especially in the optic nerve. Finally, we report the data demonstrating that Hedgehog signaling-dependency is not a universal situation for oligodendrocyte generation as evidenced in the dorsal spinal cord in contrast to the dorsal forebrain. Twit Text FOAVip Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage ????J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=29615592 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29615592 #FOAvip English Wikipedia <ref>{{Cite pmid|29615592}}</ref> Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage #MMPMID29615592 Traiffort E; Zakaria M; Laouarem Y; Ferent J J Dev Biol 2016[Sep]; 4 (3): ä PMID29615592show ga The Hedgehog morphogen aroused an enormous interest since it was characterized as an essential signal for ventral patterning of the spinal cord two decades ago. The pathway is notably implicated in the initial appearance of the progenitors of oligodendrocytes (OPCs), the glial cells of the central nervous system which after maturation are responsible for axon myelination. In accordance with the requirement for Hedgehog signaling in ventral patterning, the earliest identifiable cells in the oligodendrocyte lineage are derived from the ventral ventricular zone of the developing spinal cord and brain. Here, we present the current knowledge about the involvement of Hedgehog signaling in the strict spatial and temporal regulation which characterizes the initiation and progression of the oligodendrocyte lineage. We notably describe the ability of the Hedgehog signaling to tightly orchestrate the appearance of specific combinations of genes in concert with other pathways. We document the molecular mechanisms controlling Hedgehog temporal activity during OPC specification. The contribution of the pathway to aspects of OPC development different from their specification is also highlighted especially in the optic nerve. Finally, we report the data demonstrating that Hedgehog signaling-dependency is not a universal situation for oligodendrocyte generation as evidenced in the dorsal spinal cord in contrast to the dorsal forebrain. äHedgehog: A Key Signaling in the Development of the Oligodendrocyte Li(epmc).pdf DeepDyve Pubget Overpricing