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2018 ; 2018
(ä): 2474831
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Nephroprotective Effect of Zingerone against CCl(4)-Induced Renal Toxicity in
Swiss Albino Mice: Molecular Mechanism
#MMPMID29636837
Safhi MM
Oxid Med Cell Longev
2018[]; 2018
(ä): 2474831
PMID29636837
show ga
The protective effects of Zingerone against CCl(4) induced nephrotoxicity in
Swiss albino mice via modulation of metabolizing enzyme, oxidative stress,
inflammatory cytokines, and apoptosis. The biochemical estimation indicated that
the BUN and creatinine were significantly increased in group 2 (CCl(4)) compared
to group 1 (normal) which was significantly reduced after treatment with
Zingerone in group 3 when compared with group 2. The CCl(4) treatment has
significantly increased TBARS levels and reduced the antioxidant enzyme such as
GSH, GPx, GR, GST, CAT, and SOD in group 2 compared to group 1, while the
Zingerone treatment showed significant reduction in TBARS levels and increased
the antioxidant enzymes in group 3 (CCl(4) +?Zingerone) as compared to group 2.
Similarly, it was observed that CCl(4) significantly increased the cytokines such
as IL-1?, IL-2, and TNF? levels in group 2 as compared to group 1. The treatment
with Zingerone significantly attenuated the levels of IL-1?, IL-2, and TNF? in
group 3 compared to group 2. Caspase 3 and caspase 9 were also significantly
increased in CCl(4)-treated group 2, whereas Zingerone treatment significantly
reduced the elevated levels of caspases 3 and 9 in group 3 compared to group 2.
|Animals
[MESH]
|Chemokine CCL4/*adverse effects
[MESH]
|Guaiacol/*analogs & derivatives/pharmacology/therapeutic use
[MESH]