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10.1002/1878-0261.12162 http://scihub22266oqcxt.onion/10.1002/1878-0261.12162 C5830653!5830653 !29215776     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29215776 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Oncol 2018 ; 12 (3 ): 305-321 Nephropedia Template TP {{tp|p=29215776 |t=2018. TGF-? transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways |pdf=|usr=}}{{29215776 }} gab.com Text TGF- transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways JO: Mol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29215776 #FOAvip Transforming growth factor-beta (TGF-?) functions as a potent proliferation inhibitor and apoptosis inducer in the early stages of breast cancer, yet promotes cancer aggressiveness in the advanced stages. The dual effect of TGF-? on cancer development is known as TGF-? paradox, and the remarkable functional conversion of TGF-? is a pivotal and controversial phenomenon that has been widely investigated for decades. This phenomenon may be attributed to the cross talk between TGF-? signaling and other pathways, including EGF receptor (EGFR) signaling during cancer progression. However, the underlying mechanism by which TGF-? shifts its role from a tumor suppressor to a cancer promoter remains elusive. In this study, TGF-? is positively correlated with EGFR expression in breast cancer tissues, and a functional linkage is observed between TGF-? signaling and EGFR transactivation in breast cancer cell lines. TGF-? promotes the migration and invasion abilities of breast cancer cells, along with the increase in EGFR expression. EGFR is also essential for TGF-?-induced enhancement of these abilities of breast cancer cells. Canonical Smad3 signaling and ERK/Sp1 signaling pathways mediate TGF-?-induced EGFR upregulation. Hence, our study provided insights into a novel mechanism by which TGF-? supports breast cancer progression. Twit Text FOAVip TGF- transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways ????Mol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29215776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29215776 #FOAvip English Wikipedia <ref>{{Cite pmid|29215776 }}</ref> TGF-? transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways #MMPMID29215776 Zhao Y ; Ma J ; Fan Y ; Wang Z ; Tian R ; Ji W ; Zhang F ; Niu R Mol Oncol 2018[Mar]; 12 (3 ): 305-321 PMID29215776 show ga Transforming growth factor-beta (TGF-?) functions as a potent proliferation inhibitor and apoptosis inducer in the early stages of breast cancer, yet promotes cancer aggressiveness in the advanced stages. The dual effect of TGF-? on cancer development is known as TGF-? paradox, and the remarkable functional conversion of TGF-? is a pivotal and controversial phenomenon that has been widely investigated for decades. This phenomenon may be attributed to the cross talk between TGF-? signaling and other pathways, including EGF receptor (EGFR) signaling during cancer progression. However, the underlying mechanism by which TGF-? shifts its role from a tumor suppressor to a cancer promoter remains elusive. In this study, TGF-? is positively correlated with EGFR expression in breast cancer tissues, and a functional linkage is observed between TGF-? signaling and EGFR transactivation in breast cancer cell lines. TGF-? promotes the migration and invasion abilities of breast cancer cells, along with the increase in EGFR expression. EGFR is also essential for TGF-?-induced enhancement of these abilities of breast cancer cells. Canonical Smad3 signaling and ERK/Sp1 signaling pathways mediate TGF-?-induced EGFR upregulation. Hence, our study provided insights into a novel mechanism by which TGF-? supports breast cancer progression. |Breast Neoplasms/metabolism/*pathology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |ErbB Receptors/genetics/metabolism [MESH] |Female [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |MAP Kinase Signaling System/drug effects/physiology [MESH] |Neoplasm Invasiveness [MESH] |Smad3 Protein/genetics/*metabolism [MESH] |Sp1 Transcription Factor/genetics/*metabolism [MESH]TGF-? transactivates EGFR and facilitates breast cancer migration and (epmc).pdf DeepDyve Pubget Overpricing