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10.1038/s41467-018-02868-y http://scihub22266oqcxt.onion/10.1038/s41467-018-02868-y C5830429!5830429!29491460     free     free     free       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29491460|t=2018. High capacity in G protein-coupled receptor signaling |pdf=|usr=}}{{29491460}} gab.com Text High capacity in G protein-coupled receptor signaling JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29491460 #FOAvip G protein-coupled receptors (GPCRs) constitute a large family of receptors that activate intracellular signaling pathways upon detecting specific extracellular ligands. While many aspects of GPCR signaling have been uncovered through decades of studies, some fundamental properties, like its channel capacity?a measure of how much information a given transmission system can reliably transduce?are still debated. Previous studies concluded that GPCRs in individual cells could transmit around one bit of information about the concentration of the ligands, allowing only for a reliable on or off response. Using muscarinic receptor-induced calcium response measured in individual cells upon repeated stimulation, we show that GPCR signaling systems possess a significantly higher capacity. We estimate the channel capacity of this system to be above two, implying that at least four concentration levels of the agonist can be distinguished reliably. These findings shed light on the basic principles of GPCR signaling. Twit Text FOAVip High capacity in G protein-coupled receptor signaling ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29491460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29491460 #FOAvip English Wikipedia <ref>{{Cite pmid|29491460}}</ref> High capacity in G protein-coupled receptor signaling #MMPMID29491460 Keshelava A; Solis GP; Hersch M; Koval A; Kryuchkov M; Bergmann S; Katanaev VL Nat Commun 2018[]; 9 (ä): ä PMID29491460show ga G protein-coupled receptors (GPCRs) constitute a large family of receptors that activate intracellular signaling pathways upon detecting specific extracellular ligands. While many aspects of GPCR signaling have been uncovered through decades of studies, some fundamental properties, like its channel capacity?a measure of how much information a given transmission system can reliably transduce?are still debated. Previous studies concluded that GPCRs in individual cells could transmit around one bit of information about the concentration of the ligands, allowing only for a reliable on or off response. Using muscarinic receptor-induced calcium response measured in individual cells upon repeated stimulation, we show that GPCR signaling systems possess a significantly higher capacity. We estimate the channel capacity of this system to be above two, implying that at least four concentration levels of the agonist can be distinguished reliably. These findings shed light on the basic principles of GPCR signaling. äHigh capacity in G protein-coupled receptor signaling (epmc).pdf DeepDyve Pubget Overpricing