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10.3324/haematol.2017.183335 http://scihub22266oqcxt.onion/10.3324/haematol.2017.183335 C5830368!5830368!29439185     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Haematologica 2018 ; 103 (3): 382-94 Nephropedia Template TP {{tp|p=29439185|t=2018. Extracellular vesicles in the hematopoietic microenvironment |pdf=|usr=}}{{29439185}} gab.com Text Extracellular vesicles in the hematopoietic microenvironment JO: Haematologica http://www.kidney.de/pget.php?&tw=1&pmid=29439185 #FOAvip Self-renewal and differentiation are defining characteristics of hematopoietic stem and progenitor cells, and their balanced regulation is central to lifelong function of both blood and immune systems. In addition to cell-intrinsic programs, hematopoietic stem and progenitor cell fate decisions are subject to extrinsic cues from within the bone marrow microenvironment and systemically. Yet, many of the paracrine and endocrine mediators that shape hematopoietic function remain to be discovered. Extracellular vesicles serve as evolutionarily conserved, constitutive regulators of cell and tissue homeostasis, with several recent reports supporting a role for extracellular vesicles in the regulation of hematopoiesis. We review the physiological and pathophysiological effects that extracellular vesicles have on bone marrow compartmental function while highlighting progress in understanding vesicle biogenesis, cargo incorporation, differential uptake, and downstream effects of vesicle internalization. This review also touches on the role of extracellular vesicles in hematopoietic stem and progenitor cell fate regulation and recent advances in therapeutic and diagnostic applications of extracellular vesicles in hematologic disorders. Twit Text FOAVip Extracellular vesicles in the hematopoietic microenvironment ????Haematologica http://www.kidney.de/pget.php?&tw=1&pmid=29439185 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29439185 #FOAvip English Wikipedia <ref>{{Cite pmid|29439185}}</ref> Extracellular vesicles in the hematopoietic microenvironment #MMPMID29439185 Butler JT; Abdelhamed S; Kurre P Haematologica 2018[Mar]; 103 (3): 382-94 PMID29439185show ga Self-renewal and differentiation are defining characteristics of hematopoietic stem and progenitor cells, and their balanced regulation is central to lifelong function of both blood and immune systems. In addition to cell-intrinsic programs, hematopoietic stem and progenitor cell fate decisions are subject to extrinsic cues from within the bone marrow microenvironment and systemically. Yet, many of the paracrine and endocrine mediators that shape hematopoietic function remain to be discovered. Extracellular vesicles serve as evolutionarily conserved, constitutive regulators of cell and tissue homeostasis, with several recent reports supporting a role for extracellular vesicles in the regulation of hematopoiesis. We review the physiological and pathophysiological effects that extracellular vesicles have on bone marrow compartmental function while highlighting progress in understanding vesicle biogenesis, cargo incorporation, differential uptake, and downstream effects of vesicle internalization. This review also touches on the role of extracellular vesicles in hematopoietic stem and progenitor cell fate regulation and recent advances in therapeutic and diagnostic applications of extracellular vesicles in hematologic disorders. äExtracellular vesicles in the hematopoietic microenvironment (epmc).pdf DeepDyve Pubget Overpricing