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Tailed giant Tupanvirus possesses the most complete translational apparatus of
the known virosphere
#MMPMID29487281
Abrahão J
; Silva L
; Silva LS
; Khalil JYB
; Rodrigues R
; Arantes T
; Assis F
; Boratto P
; Andrade M
; Kroon EG
; Ribeiro B
; Bergier I
; Seligmann H
; Ghigo E
; Colson P
; Levasseur A
; Kroemer G
; Raoult D
; La Scola B
Nat Commun
2018[Feb]; 9
(1
): 749
PMID29487281
show ga
Here we report the discovery of two Tupanvirus strains, the longest tailed
Mimiviridae members isolated in amoebae. Their genomes are 1.44-1.51?Mb linear
double-strand DNA coding for 1276-1425 predicted proteins. Tupanviruses share the
same ancestors with mimivirus lineages and these giant viruses present the
largest translational apparatus within the known virosphere, with up to 70 tRNA,
20 aaRS, 11 factors for all translation steps, and factors related to tRNA/mRNA
maturation and ribosome protein modification. Moreover, two sequences with
significant similarity to intronic regions of 18?S rRNA genes are encoded by the
tupanviruses and highly expressed. In this translation-associated gene set, only
the ribosome is lacking. At high multiplicity of infections, tupanvirus is also
cytotoxic and causes a severe shutdown of ribosomal RNA and a progressive
degradation of the nucleus in host and non-host cells. The analysis of
tupanviruses constitutes a new step toward understanding the evolution of giant
viruses.
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