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2017 ; 3
(12
): e229
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Eight Weeks of Ledipasvir/Sofosbuvir in Kidney Transplant Recipients With
Hepatitis C Genotype 1 Infection
#MMPMID29536030
Husson JS
; Ravichandran B
; Jonchhe S
; Kottilil S
; Wilson E
Transplant Direct
2017[Dec]; 3
(12
): e229
PMID29536030
show ga
Short treatment duration of ledipasvir/sofosbuvir (LDV/SOF) has been successfully
used to treat hepatitis C virus (HCV) genotype 1 infection in treatment-naive
noncirrhotic patients with viral loads (VLs) under 6 million IU/mL. However, this
short duration has not been studied in renal transplant recipients (RTRs), a
patient population on lifelong immunosuppression. Here, we describe 3 RTRs who
received 8 weeks of LDV/SOF, meeting the standard criteria for shortened
treatment duration. All 3 patients tolerated treatment well and achieved
sustained virologic response at 12 weeks (SVR 12).