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2018 ; 2018
(ä): 2181602
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Choroidal and Retinal Thickness of Highly Myopic Eyes with Early Stage of Myopic
Chorioretinopathy: Tessellation
#MMPMID29607214
Zhou Y
; Song M
; Zhou M
; Liu Y
; Wang F
; Sun X
J Ophthalmol
2018[]; 2018
(ä): 2181602
PMID29607214
show ga
PURPOSE: To investigate the choroidal thickness (CT) and retinal thickness (RT)
in highly myopic tessellated eyes. METHODS: In this study, 115 highly myopic eyes
were recruited and divided as tessellated fundus (n = 93) and normal fundus (n =
22). RT and CT were quantified using optical coherence tomography with enhanced
depth imaging (EDI-OCT). Correlation between subfoveal CT (SFCT) and tessellation
was analyzed using logistic regression models. RESULTS: Tessellated fundus eyes
had thinner CT than did normal fundus eyes, while RT was not statistically
different across groups. The tessellated eyes had a thinner choroid than did the
control eyes at all measured macular locations (all P < 0.05). After adjustment
for AL, age, and gender, the SFCT was significantly associated with tessellation.
The odds ratio (OR) and 95% confidence interval (CI) was 0.975 (0.960-0.990, P =
0.001, binary logistics regression) and 0.991 (0.984-0.999, P = 0.022, Cox
regression). The area under the curve (AUC) of SFCT was the greatest for
detecting tessellation (AUC?=?0.824, P < 0.001). For sensitivity and specificity
analyses, SFCT had the highest diagnostic value (sensitivity?=?81.8%,
specificity?=?74.2%). CONCLUSIONS: Highly myopic eyes with tessellation have
thinner CT than do normal highly myopic eyes. CT may serve as an early pathologic
predictor of high myopia.