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10.1101/gad.309351.117

http://scihub22266oqcxt.onion/10.1101/gad.309351.117
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C5828392!5828392!29378787
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suck abstract from ncbi


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pmid29378787      Genes+Dev 2018 ; 32 (1): 26-41
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  • Widespread transcriptional pausing and elongation control at enhancers #MMPMID29378787
  • Henriques T; Scruggs BS; Inouye MO; Muse GW; Williams LH; Burkholder AB; Lavender CA; Fargo DC; Adelman K
  • Genes Dev 2018[Jan]; 32 (1): 26-41 PMID29378787show ga
  • In this study, Henriques et al. demonstrate that transcription is a nearly universal feature of enhancers in Drosophila and mammalian cells and that nascent RNA sequencing strategies are optimal for identification of both enhancers and superenhancers. Their findings provide insights into the unique characteristics of superenhancers, which stimulate high-level gene expression through rapid pause release; interestingly, this property renders associated genes resistant to loss of factors that stabilize paused RNAPII.
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