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2018 ; 2018
(ä): 4852359
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Hippocampal Pathophysiology: Commonality Shared by Temporal Lobe Epilepsy and
Psychiatric Disorders
#MMPMID29610762
Nakahara S
; Adachi M
; Ito H
; Matsumoto M
; Tajinda K
; van Erp TGM
Neurosci J
2018[]; 2018
(ä): 4852359
PMID29610762
show ga
Accumulating evidence points to the association of epilepsy, particularly,
temporal lobe epilepsy (TLE), with psychiatric disorders, such as schizophrenia.
Among these illnesses, the hippocampus is considered the regional focal point of
the brain, playing an important role in cognition, psychosis, and seizure
activity and potentially suggesting common etiologies and pathophysiology of TLE
and schizophrenia. In the present review, we overview abnormal network
connectivity between the dentate gyrus (DG) and the Cornus Ammonis area 3 (CA3)
subregions of the hippocampus relative to the induction of epilepsy and
schizophrenia. In light of our recent finding on the misguidance of hippocampal
mossy fiber projection in the rodent model of schizophrenia, we discuss whether
ectopic mossy fiber projection is a commonality in order to evoke TLE as well as
symptoms related to schizophrenia.