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2018 ; 9
(12
): 10784-10807
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Multi-functional, multicompartmental hyaluronan-binding protein 1
(HABP1/p32/gC1qR): implication in cancer progression and metastasis
#MMPMID29535843
Saha P
; Datta K
Oncotarget
2018[Feb]; 9
(12
): 10784-10807
PMID29535843
show ga
Cancer is a complex, multi-factorial, multi-stage disease and a global threat to
human health. Early detection of nature and stage of cancer is highly crucial for
disease management. Recent studies have proved beyond any doubt about the
involvement of the ubiquitous, myriad ligand binding, multi-functional human
protein, hyaluronan-binding protein 1 (HABP1), which is identical to the splicing
factor associated protein (p32) and the receptor of the globular head of the
complement component (gC1qR) in tumorigenesis and cancer metastasis.
Simultaneously three laboratories have discovered and named this protein
separately as mentioned. Subsequently, different scientists have worked on the
distinct functions in cellular processes ranging from immunological response,
splicing mechanism, sperm-oocyte interactions, cell cycle regulation to cancer
and have concentrated in their respective area of interest, referring it as
either p32 or gC1qR or HABP1. HABP1 overexpression has been reported in almost
all the tissue-specific forms of cancer and correlated with stage and poor
prognosis in patients. In order to tackle this deadly disease and for therapeutic
intervention, it is imperative to focus on all the regulatory aspects of this
protein. Hence, this work is an attempt to combine an assortment of information
on this protein to have an overview, which suggests its use as a diagnostic
marker for cancer. The knowledge might assist in the designing of drugs for
therapeutic intervention of HABP1/p32/gC1qR regulated specific ligand mediated
pathways in cancer.
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