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Lactic Acid Bacteria Isolated from Japanese Fermented Fish (Funa-Sushi) Inhibit
Mesangial Proliferative Glomerulonephritis by Alcohol Intake with Stress
#MMPMID29607219
Yamada Y
; Endou M
; Morikawa S
; Shima J
; Komatshzaki N
J Nutr Metab
2018[]; 2018
(?): 6491907
PMID29607219
show ga
The aim of this study was to examine the effect of heat-killed Lactobacillus
paracasei NFRI 7415 on kidney and bone in mice fed an ethanol-containing diet
with stress. Eight-week-old Cril??:??CD1 mice were fed a control diet (CD), an
alcohol diet (AD) (35.8% of total energy from ethanol), or an alcohol diet
containing 20% heat-killed Lb. paracasei NFRI 7415 (10(7)?CFU/g) (LD) for 4
weeks. Mice in the AD and LD groups also underwent restraint stress for two weeks
from 13 days. The mice were placed in a 50?mL plastic tube, which had a small
hole drilled around its base to allow ventilation, and restrained for 1?h every
day. High final body weight was in the following order: CD, LD, and AD (p <
0.05). The heat-killed Lb. paracasei NFRI 7415 lowered liver total cholesterol
concentration and plasma glutamic-oxaloacetic transaminase (GOT) level. In
addition, fecal bile acids of the LD group were higher than in the AD group (p <
0.05). The glomerulus of the kidney in the AD group was observed to be more
fibrotic than in the CD and LD groups with azan stain. Immunostaining confirmed
that brown areas indicating the existence of mesangial cells were increased in
the AD group, but not in the CD and LD groups. These results indicated that the
heat-killed Lb. paracasei NFRI 7415 inhibited mesangial proliferative
glomerulonephritis by alcohol intake with stress.
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