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10.1038/s41598-018-21812-0 http://scihub22266oqcxt.onion/10.1038/s41598-018-21812-0 C5827654!5827654 !29483552     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29483552 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 3624 Nephropedia Template TP {{tp|p=29483552 |t=2018. Activation of AMPK inhibits TGF-?1-induced airway smooth muscle cells proliferation and its potential mechanisms |pdf=|usr=}}{{29483552 }} gab.com Text Activation of AMPK inhibits TGF- 1-induced airway smooth muscle cells proliferation and its potential mechanisms JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29483552 #FOAvip The aims of the present study were to examine signaling mechanisms underlying transforming growth factor ?1 (TGF-?1)-induced airway smooth muscle cells (ASMCs) proliferation and to determine the effect of adenosine monophosphate-activated protein kinase (AMPK) activation on TGF-?1-induced ASMCs proliferation and its potential mechanisms. TGF-?1 reduced microRNA-206 (miR-206) level by activating Smad2/3, and this in turn up-regulated histone deacetylase 4 (HDAC4) and consequently increased cyclin D1 protein leading to ASMCs proliferation. Prior incubation of ASMCs with metformin induced AMPK activation and blocked TGF-?1-induced cell proliferation. Activation of AMPK slightly attenuated TGF-?1-induced miR-206 suppression, but dramatically suppressed TGF-?1-caused HDAC4 up-expression and significantly increased HDAC4 phosphorylation finally leading to reduction of up-regulated cyclin D1 protein expression. Our study suggests that activation of AMPK modulates miR-206/HDAC4/cyclin D1 signaling pathway, particularly targeting on HDAC4, to suppress ASMCs proliferation and therefore has a potential value in the prevention and treatment of asthma by alleviating airway remodeling. Twit Text FOAVip Activation of AMPK inhibits TGF- 1-induced airway smooth muscle cells proliferation and its potential mechanisms ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29483552 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29483552 #FOAvip English Wikipedia <ref>{{Cite pmid|29483552 }}</ref> Activation of AMPK inhibits TGF-?1-induced airway smooth muscle cells proliferation and its potential mechanisms #MMPMID29483552 Pan Y ; Liu L ; Li S ; Wang K ; Ke R ; Shi W ; Wang J ; Yan X ; Zhang Q ; Wang Q ; Chai L ; Xie X ; Li M Sci Rep 2018[Feb]; 8 (1 ): 3624 PMID29483552 show ga The aims of the present study were to examine signaling mechanisms underlying transforming growth factor ?1 (TGF-?1)-induced airway smooth muscle cells (ASMCs) proliferation and to determine the effect of adenosine monophosphate-activated protein kinase (AMPK) activation on TGF-?1-induced ASMCs proliferation and its potential mechanisms. TGF-?1 reduced microRNA-206 (miR-206) level by activating Smad2/3, and this in turn up-regulated histone deacetylase 4 (HDAC4) and consequently increased cyclin D1 protein leading to ASMCs proliferation. Prior incubation of ASMCs with metformin induced AMPK activation and blocked TGF-?1-induced cell proliferation. Activation of AMPK slightly attenuated TGF-?1-induced miR-206 suppression, but dramatically suppressed TGF-?1-caused HDAC4 up-expression and significantly increased HDAC4 phosphorylation finally leading to reduction of up-regulated cyclin D1 protein expression. Our study suggests that activation of AMPK modulates miR-206/HDAC4/cyclin D1 signaling pathway, particularly targeting on HDAC4, to suppress ASMCs proliferation and therefore has a potential value in the prevention and treatment of asthma by alleviating airway remodeling. |AMP-Activated Protein Kinases/genetics/*metabolism [MESH] |Animals [MESH] |Cell Proliferation/drug effects [MESH] |Cells, Cultured [MESH] |Histone Deacetylases/genetics/*metabolism [MESH] |Immunoblotting [MESH] |MicroRNAs/genetics/metabolism [MESH] |Myocytes, Smooth Muscle/*cytology/*drug effects [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Signal Transduction/drug effects [MESH]Activation of AMPK inhibits TGF-?1-induced airway smooth muscle cells (epmc).pdf DeepDyve Pubget Overpricing