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10.1038/s41467-018-03105-2 http://scihub22266oqcxt.onion/10.1038/s41467-018-03105-2 C5827027!5827027 !29483579     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29483579 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2018 ; 9 (1 ): 816 Nephropedia Template TP {{tp|p=29483579 |t=2018. Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury |pdf=|usr=}}{{29483579 }} gab.com Text Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29483579 #FOAvip Myocardial ischemia-reperfusion injury (IRI) leads to the stabilization of the transcription factors hypoxia-inducible factor 1-alpha (HIF1-alpha) and hypoxia-inducible factor 2-alpha (HIF2-alpha). While previous studies implicate HIF1-alpha in cardioprotection, the role of HIF2-alpha remains elusive. Here we show that HIF2-alpha induces the epithelial growth factor amphiregulin (AREG) to elicit cardioprotection in myocardial IRI. Comparing mice with inducible deletion of Hif1a or Hif2a in cardiac myocytes, we show that loss of Hif2-alpha increases infarct sizes. Microarray studies in genetic models or cultured human cardiac myocytes implicate HIF2-alpha in the myocardial induction of AREG. Likewise, AREG increases in myocardial tissues from patients with ischemic heart disease. Areg deficiency increases myocardial IRI, as does pharmacologic inhibition of Areg signaling. In contrast, treatment with recombinant Areg provides cardioprotection and reconstitutes mice with Hif2a deletion. These studies indicate that HIF2-alpha induces myocardial AREG expression in cardiac myocytes, which increases myocardial ischemia tolerance. Twit Text FOAVip Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29483579 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29483579 #FOAvip English Wikipedia <ref>{{Cite pmid|29483579 }}</ref> Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury #MMPMID29483579 Koeppen M ; Lee JW ; Seo SW ; Brodsky KS ; Kreth S ; Yang IV ; Buttrick PM ; Eckle T ; Eltzschig HK Nat Commun 2018[Feb]; 9 (1 ): 816 PMID29483579 show ga Myocardial ischemia-reperfusion injury (IRI) leads to the stabilization of the transcription factors hypoxia-inducible factor 1-alpha (HIF1-alpha) and hypoxia-inducible factor 2-alpha (HIF2-alpha). While previous studies implicate HIF1-alpha in cardioprotection, the role of HIF2-alpha remains elusive. Here we show that HIF2-alpha induces the epithelial growth factor amphiregulin (AREG) to elicit cardioprotection in myocardial IRI. Comparing mice with inducible deletion of Hif1a or Hif2a in cardiac myocytes, we show that loss of Hif2-alpha increases infarct sizes. Microarray studies in genetic models or cultured human cardiac myocytes implicate HIF2-alpha in the myocardial induction of AREG. Likewise, AREG increases in myocardial tissues from patients with ischemic heart disease. Areg deficiency increases myocardial IRI, as does pharmacologic inhibition of Areg signaling. In contrast, treatment with recombinant Areg provides cardioprotection and reconstitutes mice with Hif2a deletion. These studies indicate that HIF2-alpha induces myocardial AREG expression in cardiac myocytes, which increases myocardial ischemia tolerance. |Amphiregulin/*genetics/metabolism/pharmacology [MESH] |Animals [MESH] |Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors/*genetics/metabolism [MESH] |Cell Line [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors/*genetics/metabolism [MESH] |Integrases/genetics/metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Microarray Analysis [MESH] |Myocardial Reperfusion Injury/*genetics/metabolism/pathology/prevention & control [MESH] |Myocardium/*metabolism/pathology [MESH] |Myocytes, Cardiac/drug effects/*metabolism/pathology [MESH] |Myosins/genetics/metabolism [MESH] |RNA, Small Interfering/genetics/metabolism [MESH]Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin d(epmc).pdf DeepDyve Pubget Overpricing