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10.1038/ncb3586 http://scihub22266oqcxt.onion/10.1038/ncb3586 C5826565!5826565!28759028     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2017 ; 19 (9): 1061-70 Nephropedia Template TP {{tp|p=28759028|t=2017. Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence |pdf=|usr=}}{{28759028}} gab.com Text Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28759028 #FOAvip Cellular senescence is triggered by various distinct stresses and characterized by a permanent cell cycle arrest. Senescent cells secrete a variety of inflammatory factors, collectively referred to as the senescence-associated secretory phenotype (SASP). The mechanism(s) underlying the regulation of the SASP remains incompletely understood. Here we define a role for innate DNA sensing in the regulation of senescence and the SASP. We find that cyclic GMP-AMP synthase (cGAS) recognizes cytosolic chromatin fragments (CCFs) in senescent cells. The activation of cGAS, in turn triggers the production of SASP factors via Stimulator of interferon genes (STING), thereby promoting paracrine senescence. We demonstrate that diverse stimuli of cellular senescence engage the cGAS-STING pathway in vitro and we show cGAS-dependent regulation of senescence upon irradiation and oncogene activation in vivo. Our findings provide insights into the mechanisms underlying cellular senescence by establishing the cGAS-STING pathway as a crucial regulator of senescence and the SASP. Twit Text FOAVip Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28759028 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28759028 #FOAvip English Wikipedia <ref>{{Cite pmid|28759028}}</ref> Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence #MMPMID28759028 Glück S; Guey B; Gulen MF; Wolter K; Kang TW; Schmacke NA; Bridgeman A; Rehwinkel J; Zender L; Ablasser A Nat Cell Biol 2017[Sep]; 19 (9): 1061-70 PMID28759028show ga Cellular senescence is triggered by various distinct stresses and characterized by a permanent cell cycle arrest. Senescent cells secrete a variety of inflammatory factors, collectively referred to as the senescence-associated secretory phenotype (SASP). The mechanism(s) underlying the regulation of the SASP remains incompletely understood. Here we define a role for innate DNA sensing in the regulation of senescence and the SASP. We find that cyclic GMP-AMP synthase (cGAS) recognizes cytosolic chromatin fragments (CCFs) in senescent cells. The activation of cGAS, in turn triggers the production of SASP factors via Stimulator of interferon genes (STING), thereby promoting paracrine senescence. We demonstrate that diverse stimuli of cellular senescence engage the cGAS-STING pathway in vitro and we show cGAS-dependent regulation of senescence upon irradiation and oncogene activation in vivo. Our findings provide insights into the mechanisms underlying cellular senescence by establishing the cGAS-STING pathway as a crucial regulator of senescence and the SASP. äInnate immune sensing of cytosolic chromatin fragments through cGAS pr(epmc).pdf DeepDyve Pubget Overpricing