Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29481564
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Short-term renal outcomes following acute kidney injury among dengue patients: A
follow-up analysis from large prospective cohort
#MMPMID29481564
Mallhi TH
; Khan AH
; Adnan AS
; Sarriff A
; Khan YH
; Gan SH
PLoS One
2018[]; 13
(2
): e0192510
PMID29481564
show ga
BACKGROUND: Despite myriad improvements in the care of dengue patients, acute
kidney injury (AKI) remained least appreciated intricacy of dengue infection.
Exiting literature does not provide any information on renal outcomes among
dengue patients surviving an episode of AKI. METHODS: Dengue patients who
developed AKI were followed up for post-discharge period of three months and
renal recovery was assessed by using recovery criteria based on different
thresholds of serum creatinine (SCr) and estimated glomerular filtration rates
(eGFR). RESULTS: Out of the 526 dengue participants, AKI was developed in 72
(13.7%) patients. Renal recovery was assessed among AKI survivors (n = 71). The
use of less (±50% recovery to baseline) to more (±5% recovery to baseline)
stringent definitions of renal recovery yielded recovery rates from 88.9% to 2.8%
by SCr and 94.4% to 5.6% by eGFR, as renal function biomarkers. At the end of
study, eight patients had AKI with AKIN-II (n = 7) and AKIN-III (n = 1).
Approximately 50% patients (n = 36/71) with AKI had eGFR primitive to CKD stage
2, while 18.3% (n = 13/71) and 4.2% (n = 3/71) patients had eGFR corresponding to
advanced stages of CKD (stage 3 & 4). Factors such as renal insufficiencies at
hospital discharge, multiple organ involvements, advance age, female gender and
diabetes mellitus were associated with poor renal outcomes. CONCLUSIONS: We
conclude that dengue patients with AKI portend unsatisfactory short-term renal
outcomes and deserve a careful and longer follow-up, especially under nephrology
care.