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10.3389/fimmu.2018.00288 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00288 C5826238!5826238!29515586     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29515586|t=2018. The Neutrophil?s Choice: Phagocytose vs Make Neutrophil Extracellular Traps |pdf=|usr=}}{{29515586}} gab.com Text The Neutrophil s Choice: Phagocytose vs Make Neutrophil Extracellular Traps JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29515586 #FOAvip Neutrophils recognize particulate substrates of microbial or endogenous origin and react by sequestering the cargo via phagocytosis or by releasing neutrophil extracellular traps (NETs) outside the cell, thus modifying and alerting the environment and bystander leukocytes. The signals that determine the choice between phagocytosis and the generation of NETs are still poorly characterized. Neutrophils that had phagocytosed bulky particulate substrates, such as apoptotic cells and activated platelets, appear to be ?poised? in an unresponsive state. Environmental conditions, the metabolic, adhesive and activation state of the phagocyte, and the size of and signals associated with the tethered phagocytic cargo influence the choice of the neutrophils, prompting either phagocytic clearance or the generation of NETs. The choice is dichotomic and apparently irreversible. Defects in phagocytosis may foster the intravascular generation of NETs, thus promoting vascular inflammation and morbidities associated with diseases characterized by defective phagocytic clearance, such as systemic lupus erythematosus. There is a strong potential for novel treatments based on new knowledge of the events determining the inflammatory and pro-thrombotic function of inflammatory leukocytes. Twit Text FOAVip The Neutrophil s Choice: Phagocytose vs Make Neutrophil Extracellular Traps ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29515586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29515586 #FOAvip English Wikipedia <ref>{{Cite pmid|29515586}}</ref> The Neutrophil?s Choice: Phagocytose vs Make Neutrophil Extracellular Traps #MMPMID29515586 Manfredi AA; Ramirez GA; Rovere-Querini P; Maugeri N Front Immunol 2018[]; 9 (ä): ä PMID29515586show ga Neutrophils recognize particulate substrates of microbial or endogenous origin and react by sequestering the cargo via phagocytosis or by releasing neutrophil extracellular traps (NETs) outside the cell, thus modifying and alerting the environment and bystander leukocytes. The signals that determine the choice between phagocytosis and the generation of NETs are still poorly characterized. Neutrophils that had phagocytosed bulky particulate substrates, such as apoptotic cells and activated platelets, appear to be ?poised? in an unresponsive state. Environmental conditions, the metabolic, adhesive and activation state of the phagocyte, and the size of and signals associated with the tethered phagocytic cargo influence the choice of the neutrophils, prompting either phagocytic clearance or the generation of NETs. The choice is dichotomic and apparently irreversible. Defects in phagocytosis may foster the intravascular generation of NETs, thus promoting vascular inflammation and morbidities associated with diseases characterized by defective phagocytic clearance, such as systemic lupus erythematosus. There is a strong potential for novel treatments based on new knowledge of the events determining the inflammatory and pro-thrombotic function of inflammatory leukocytes. äThe Neutrophil?s Choice: Phagocytose vs Make Neutrophil Extracellular (epmc).pdf DeepDyve Pubget Overpricing