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10.1080/19420889.2018.1433440

http://scihub22266oqcxt.onion/10.1080/19420889.2018.1433440
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C5824965!5824965!29497473
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suck abstract from ncbi


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pmid29497473      Commun+Integr+Biol 2018 ; 11 (1): ä
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  • Booting up the organism during development: Pre-behavioral functions of the vertebrate brain in guiding body morphogenesis #MMPMID29497473
  • Herrera-Rincon C; Levin M
  • Commun Integr Biol 2018[]; 11 (1): ä PMID29497473show ga
  • A recent study in Xenopus laevis embryos showed that the very early brain has important functions long before behavior. While the nascent brain is being constructed, it is required for normal patterning of the muscle and peripheral nerve networks, including those far away from the head. In addition to providing important developmental signals to remote tissues in normal embryogenesis, its presence is also able to render harmless exposure to specific chemicals that normally act as teratogens. These activities of the early brain can be partially compensated for in a brainless embryo by experimental modulation of neurotransmitter and ion channel signaling. Here, we discuss the major findings of this paper in the broader context of developmental physiology, neuroscience, and biomedicine. This novel function of the embryonic brain has significant implications, especially for understanding developmental toxicology and teratogenesis in the context of pharmaceutical and environmental reagents.
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