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2018 ; 11
(1
): e1433440
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Booting up the organism during development: Pre-behavioral functions of the
vertebrate brain in guiding body morphogenesis
#MMPMID29497473
Herrera-Rincon C
; Levin M
Commun Integr Biol
2018[]; 11
(1
): e1433440
PMID29497473
show ga
A recent study in Xenopus laevis embryos showed that the very early brain has
important functions long before behavior. While the nascent brain is being
constructed, it is required for normal patterning of the muscle and peripheral
nerve networks, including those far away from the head. In addition to providing
important developmental signals to remote tissues in normal embryogenesis, its
presence is also able to render harmless exposure to specific chemicals that
normally act as teratogens. These activities of the early brain can be partially
compensated for in a brainless embryo by experimental modulation of
neurotransmitter and ion channel signaling. Here, we discuss the major findings
of this paper in the broader context of developmental physiology, neuroscience,
and biomedicine. This novel function of the embryonic brain has significant
implications, especially for understanding developmental toxicology and
teratogenesis in the context of pharmaceutical and environmental reagents.