How does hepcidin hinder ferroportin activity? #MMPMID29472371
Zhang DL; Rouault TA
Blood 2018[Feb]; 131 (8): 840-2 PMID29472371show ga
In this issue of Blood, Aschemeyer et al found that hepcidin bound to the central cavity of ferroportin (Fpn) and occluded its iron export activity, thereby revealing a previously unrecognized mechanism for Fpn regulation.1